Liquid purification or separation – Processes – Chromatography
Reexamination Certificate
2007-05-08
2007-05-08
Therkorn, Ernest G. (Department: 1723)
Liquid purification or separation
Processes
Chromatography
C210S143000, C210S198200, C422S070000, C422S105000, C073S061520, C073S061560, C073S061580
Reexamination Certificate
active
10979946
ABSTRACT:
Systems and methods for analyzing a plurality of samples in parallel include a plurality of liquid phase separation regions, a plurality of microfluidic storage regions, and a common mass spectrometer. Samples are separated in parallel in the separation regions to yield a plurality of output streams that are stored in the storage regions. The contents of each storage region, or at least a representative portion thereof, are sequentially discharged, ionized, and directed to the inlet of a mass spectrometer. In this manner, multiple separations are conducted in parallel with outputs provided serially to a common mass spectrometer without any loss of data. Microfluidic storage regions minimize diffusion between bands of separated samples. Portions of separated samples may be directed to fraction collectors.
REFERENCES:
patent: 5872010 (1999-02-01), Karger et al.
patent: 6054047 (2000-04-01), Hindsgaul et al.
patent: 6066848 (2000-05-01), Kassel et al.
patent: 6264892 (2001-07-01), Kaltenbach et al.
patent: 6318157 (2001-11-01), Corso et al.
patent: 6410915 (2002-06-01), Bateman et al.
patent: 6436292 (2002-08-01), Petro
patent: 6481453 (2002-11-01), O'Connor et al.
patent: 6508938 (2003-01-01), Maiefski et al.
patent: 6541768 (2003-04-01), Andrien, Jr. et al.
patent: 6621075 (2003-09-01), Hindsgaul et al.
patent: 6632404 (2003-10-01), Freitag et al.
patent: 6641783 (2003-11-01), Pidgeon et al.
patent: 6649908 (2003-11-01), Apffel, Jr. et al.
patent: 6656739 (2003-12-01), Hindsgaul et al.
patent: 6762406 (2004-07-01), Cooks et al.
patent: 6812030 (2004-11-01), Ozbal et al.
patent: 6812458 (2004-11-01), Gregori et al.
patent: 6855258 (2005-02-01), Petro et al.
patent: 6910503 (2005-06-01), Schick et al.
patent: 6936167 (2005-08-01), Hobbs et al.
patent: 6976384 (2005-12-01), Hobbs et al.
patent: 2002/0017484 (2002-02-01), Dourdeville
patent: 2002/0068366 (2002-06-01), LaDine, et al.
patent: 2002/0185184 (2002-12-01), O'Connor et al.
patent: 2002/0187560 (2002-12-01), Pezzuto et al.
patent: 2002/0189947 (2002-12-01), Paul, et al.
patent: 2003/0136904 (2003-07-01), Mukaibatake
patent: 2003/0162304 (2003-08-01), Dority et al.
patent: 2004/0026617 (2004-02-01), Gregori et al.
patent: WO-97/04297 (1997-02-01), None
patent: WO-9809315 (1998-03-01), None
patent: WO-00/41214 (2000-07-01), None
patent: WO-00/64557 (2000-11-01), None
patent: WO-02/30486 (2002-04-01), None
patent: WO-02/44684 (2002-06-01), None
Abian, J., The coupling of gas and liquid chromatography with mass spectrometry, J. Mass Spect., Mar. 1999, pp. 157-168, vol. 34, No. 3.
Dunn, John A., et al., A parallel LC/MS/MS system for the high throughput quantification of clinical trial samples. A validation study, waters Micromass Application Note, Oct. 2002, Publisher: Waters Micromass Technologies.
Figeys, Daniel, et al., An Integrated Microfluidics-Tandem Mass Spectrometry System for Automated Protein Analysis, Anal. Chem., Sep. 15, 1998, pp. 3728-3734, vol. 70, No. 18.
Janiszewski, John S., et al., A High-Capacity LC/MS System for the Bioanalysis of Samples Generated from Plate-Based Metabolic Screening, Anal. Chem:, Apr. 1, 2001, pp. 1459-1501, vol. 73, No. 7.
Jiang, Yun, et al., Intergrated Plastic Microfludic Devices with ESI-MS for Drug Screening and Residue Analysis , Anal. Chem., May 1, 2001, pp. 2048-2053, vol. 73, No. 9.
Kameoka, Jun, et al., A Polymeric Microfludic Chip for CE/MS Determination of Small Molecules, Anal. Chem., May 1, 2001, pp. 1935-1941, vol. 73, No. 9.
Liu, H., et al., A 96-Channel Microdevice for High Throughput Electrospray Ionization Mass Spectrometry (ESI/MS), Web document published at: http://www.geocities.com/ResearchTriangle/Lab/4688/ht-ms.html, Jun. 9, 1998.
Lin, Yuehe, et al., Microfluidic devices on polymer substrates for bioanalytical applications, Web document published at: http://www.pnl.gov/microcats/aboutus/publications/microchemical/Microtechpresentation.pdf, 1999.
Little, David, et al., A prallel LC-MS/MS system for high throughput quantification in drug discovery, Micromass Application Note 248, May 2000, Publisher: Micromass Technologies.
Misharin, Alexander S., et al., High-Throughput Mass Spectrometer Using Atmospheric Pressure Ionization and a Cylindrical Ion Trap Array , Anal. Chem., Jan. 15, 2005, pp. 459-470, vol. 77, No. 2.
Moore, Roger E., et al., A Microscale Electrospray Interface Incorporating a Monolithic, Poly(styrene-divinylbenzene) Support for On-Line Liquid, Anal. Chem., Dec. 1, 1998, pp. 4879-4884, vol. 70, No. 23.
Multi-Paraellel-HPLC, Published on the web at http://www.sepiatec.com/download/phplc.pdf, Publisher: SEPIAtec GmbH, Published in : Berlin Germany.
HPLC: Micro LC/MS analysis of biological samples, Web publication; http://www.sge.com, Apr. 1, 1998.
Van Pelt, Colleen K., et al., A Four-Column Parallel Chromatography System for Isocratic or Gradient LC/MS Analyses, Anal. Chem., Feb. 1, 2001, pp. 582-588, vol. 73, No. 3.
Wachs, Timothy, et al., Electrospray Device for Coupling Microscale Separations and Other Miniaturized Devices with Electrospray Mass . . . , Anal. Chem., Feb. 1 , 2001, pp. 632-638, vol. 73, No. 3.
Wagner, Knut, et al., An Automated On-Line Multidimensional HPLC System for Protein and Peptide Mapping with Integrated Sample Preparation, Anal. Chem., Feb. 15, 2002, pp. 809-820, vol. 74, No. 4.
Xu, Rongda, et al., Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stablility screening of . . . , J. Am. Soc. Mass Spectrom., Feb. 2002, pp. 155-165, vol. 13, No. 2.
Xu, Rongda, et al., High-Throughput Mass-Directed Parallel Purification Incorporating a Multiplexed Single Quadrupole Mass Spectrometer, Anal. Chem., Jul. 1, 2002, pp. 3055-3062, vol. 74, No. 13.
Yang, Liyu, et al., Evaluation of a Four-Channel Multiplexed Electrospray Triple Quadrupole Mass Spectrometer for the Simultaneous . . . , Anal. Chem., Apr. 15, 2001, pp. 1740-1747, vol, 73, No. 8.
Zhang, B., et al., Microfabricated Devices for Capillary Electrophoresis-Electrospray Mass Spectrometry , Anal. Chem., Aug. 1, 1999, pp. 3258-3264, vol. 71, No. 15.
Zweigenbaum, Jerry et al., High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours, Anal. Chem., Jul.1, 1999, pp. 2294-2300, vol. 71, No. 13.
Covington Joseph F.
Gregori Matthew M.
Hobbs Steven E.
Gustafson Vincent K.
Intellectual Property / Technology Law
Nanostream, Inc.
Therkorn Ernest G.
LandOfFree
Systems and methods for high throughput sample analysis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Systems and methods for high throughput sample analysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for high throughput sample analysis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3781699