Image analysis – Applications – Biomedical applications
Reexamination Certificate
2007-08-24
2010-10-26
Ishrat, Sherali (Department: 2624)
Image analysis
Applications
Biomedical applications
Reexamination Certificate
active
07822249
ABSTRACT:
Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
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Bhatla Anubha
Brenner David J.
Dutta Aparajita
Garty Guy
Lyulko Oleksandra V.
Ishrat Sherali
Sonnenschein Nath & Rosenthal LLP
The Trustees of Columbia University in the City of New York
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