Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2007-12-04
2007-12-04
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009360, C424S009600
Reexamination Certificate
active
10252311
ABSTRACT:
This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional/metabolic information to be obtained simultaneously.
REFERENCES:
patent: 5900228 (1999-05-01), Meade et al.
patent: 6083486 (2000-07-01), Weissleder et al.
patent: 6123921 (2000-09-01), Meade et al.
patent: 6217848 (2001-04-01), Achilefu et al.
patent: WO 02/00265 (2002-01-01), None
Josephson et al. Bioconjugate Chem. 2002, 13, 554-560.
Huber et al. Bioconjugate chem. 1998, 9, 242-249.
Sanjay Tyagi et al., “Molecular Beacons: Probes that Fluoresce upon Hybridization”, Nature Biotechnology, vol. 14, Mar. 1996, pp. 303-308, XP002926498.
International Search Report for International Application No. PCT/US03/25184, Date of Mailing: Feb. 9, 2004.
Bremer, Christoph et al.,Optical Imaging of Matrix Metalloproteinase-2 Activity in Tumors: Feasibility Study in a Mouse Model, RADIOLOGY, Nov. 2001, pp. 523-529.
Bremer, Christoph et al.,In Vivo Molecular Target Assessment of Matrix Metalloproteinase Inhibition, Nature Medicine, vol. 7, No. 6, Jun. 2001, pp. 743-748.
Tung, Ching-Hsuan et al.,In Vivo Imaging of Proteolytic Enzyme Activity Using a Novel Molecular Reporter, Cancer Research, Sep. 1, 2000, pp. 4953-4958.
Mahmood, Umar et al.,Near-Infrared Optical Imaging of Protease Activity for Tumor Detection, RADIOLOGY, Dec. 1999, pp. 866-870.
Tung, Ching-Hsuan et al.,Preparation of a Cathepsin D Sensitive Near-Infrared Fluorescence Probe for Imaging, Bioconjugate Chem., vol. 10, No. 5, 1999, pp. 892-896.
Weissleder, Ralph et al.,In Vivo Imaging of Tumors with Protease-Activated Near-Infrared Fluorescent Probes, Nature Biotechnology, vol. 17, Apr. 1999, pp. 375-378.
Achilefu, Samuel et al.,Novel Receptor-Targeted Fluorescent Contrast Agents for In vivo Tumor Imaging, Investigative Radiology, vol. 35, Aug. 2000, pp. 479-485.
Huber, Martina M. et al.,Fluorescently Detectable Magnetic Resonance Imaging Agents, Bioconjugate Chem., vol. 9, No. 2, 1998, pp. 242-249.
Becker, Andreas et al.,Receptor-Targeted Optical Imaging of Tumors with Near-Infrared Fluorescent Ligands, Nature Biotechnology, vol. 19, Apr. 2001, pp. 327-331.
Licha, Kai et al.,Synthesis, Characterization, and Biological Properties of Cyanine-Labeled Somatostatin Analogues as Receptor-Targeted Fluorescent Probes, Bioconjugate Chem., vol. 12, No. 1, 2001, pp. 44-50.
Becker, Andreas et al.,Cyanine Dye Labeled Vasoactive Intestinal Peptide and Somatostatin Analog for Optical Detection of Gastroenteropancreatic Tumors, Annals of the New York Academy of Sciences, vol. 921, Dec. 2000, pp. 275-278.
Josephson, Lee et al.,Near-Infrared Fluorescent Nanoparticles as Combined MR/Optical Imaging Probes, Bioconjugate Chem., vol. 13, No. 3, 2002, pp. 554-560.
Amaratunga Mohan Mark
Dhawale Paritosh
Hancu Ileana
Ishaque Nadeem
Johnson Bruce Fletcher
Cantor & Colburn LLP
General Electric Company
Hartley Michael G.
Rogers J
LandOfFree
Systems and methods for high-resolution in vivo imaging of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Systems and methods for high-resolution in vivo imaging of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for high-resolution in vivo imaging of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3859640