Systems and methods for drug infusion with feedback control

Details Systems and methods for drug infusion with feedback control Systems and methods for drug infusion with feedback control

2007-12-18

2010-06-29

Lucchesi, Nicholas D (Department: 3763)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C604S096010

Reexamination Certificate

active

07744559

ABSTRACT:
A system and method for infusing a drug under continuous positive pressure (such as convection enhanced deliver) to a target tissue to be treated is particularly useful for post-resection anticancer drug therapy. The system comprises a drug infusion catheter having an expandable device which is expanded within the target tissue such that the target tissue conforms to an outer surface of the expandable device, thereby creating a form of seal around the target volume in order to maintain an effective drug pressure gradient within the target tissue. The system further comprises a sensor to measure a parameter which can be correlated to the degree of conformance between the target tissue and the outer surface of the expandable device. The sensor is coupled to a feedback control system to determine whether there is a loss of conformance, and to adjust the expansion of the expandable device in order to maintain good conformance.

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