Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Reexamination Certificate
2004-02-04
2009-02-03
Egwim, Kelechi C (Department: 1796)
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
C524S557000, C524S916000, C525S056000, C525S061000
Reexamination Certificate
active
07485670
ABSTRACT:
In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
REFERENCES:
patent: 3875302 (1975-04-01), Inoue
patent: 4472542 (1984-09-01), Nambu
patent: 4663358 (1987-05-01), Hyon et al.
patent: 4772287 (1988-09-01), Ray et al.
patent: 4904260 (1990-02-01), Ray et al.
patent: 5047055 (1991-09-01), Bao et al.
patent: 5071437 (1991-12-01), Steffee
patent: 5260066 (1993-11-01), Wood et al.
patent: 5288503 (1994-02-01), Wood et al.
patent: 5385606 (1995-01-01), Kowanko
patent: 5534028 (1996-07-01), Bao et al.
patent: 5705296 (1998-01-01), Kamauchi et al.
patent: 5731005 (1998-03-01), Ottoboni et al.
patent: 5880216 (1999-03-01), Tanihara et al.
patent: 5976186 (1999-11-01), Bao et al.
patent: 5981826 (1999-11-01), Ku et al.
patent: 6231605 (2001-05-01), Ku
patent: 6264695 (2001-07-01), Stoy
patent: 6268405 (2001-07-01), Yao et al.
patent: 6423333 (2002-07-01), Stedronsky et al.
patent: 6520992 (2003-02-01), Zollner et al.
patent: 7001431 (2006-02-01), Bao et al.
patent: 7214245 (2007-05-01), Marcolongo et al.
patent: 2004/0092653 (2004-05-01), Ruberti
patent: 2004/0171740 (2004-09-01), Ruberti
patent: 2005/0112186 (2005-05-01), Devore et al.
patent: 2005/0288789 (2005-12-01), Chaouk et al.
patent: 2007/0100349 (2007-05-01), O'Neil et al.
patent: 1 229 873 (2002-08-01), None
patent: 03215417 (1991-09-01), None
patent: 04338326 (1992-11-01), None
patent: WO 01/12107 (2001-02-01), None
patent: WO 02/054978 (2002-07-01), None
Translation to JP 04338326 (Nov. 25, 1992).
Translation to JP 03215417 (Sep. 20, 1991).
AAOS, Musculoskeletal Conditions in the U.S., Feb. 1992-1998, AAOS.
Bao, Q.B., & Yuan, H. A., “Nucleus Replacement,” Spine, vol. 27, No. 11, 2002, 1245-1247.
Bao, Q. & Yuan, H.A, “Prosthetic Disc Replacement: The Future?,” Clinical Orthopaedics and Related Research, No. 394, pp. 139-145, 2002.
Bao, Q. et al, “The artificial disc: theory, design and materials,” Biomaterials vol. 17, No. 12, (1996) 1157-1167.
Bray, J.C. & Merrill, E. W., “Poly(vinyl Alcohol) Hydrogels. Formation by Electron Beam Irradiation of Aqueous Solutions and Subsequent Crystallization,” Journal of Applied Polymer Science, vol. 17, pp. 3779-3794, 1973.
Bray, J.C. & Merrill, E. W., “Poly(vinyl alcohol) Hydrogels for Synthetic Articular Cartilage Material,” Biomed. Mater. Res., vol. 7, pp. 431-443 1973.
Choi, J. H., et al., “Rheological Properties of Syndiotacticity-Rich Ultrahigh Molecular Weight Poly(vinyl alcohol) Dilute Solution,” Journal of Applied Polymer Science, vol. 82, 569-576 (2001).
Damshkaln, L. G., et al, Study of Cryostructuration of Polymer Systems. XV. Freeze-Thaw-Induced Formation of Cryoprecipitate Matter from Low-Concentrated Aquenous Solutions of Poly(vinyl alcohol), Journal of Applied Polymer Science, vol. 74, 1978-1986 (1999).
Darwin, D., et al, “Characterization of poly(vinyl alcohol) hydrogel for prosthetic intervetebral disc nucleus,” Radiation Physics and Chemistry 63 (2002) 539-542.
de Gennes, P.G., “Scaling Concepts in Polymer Physics,” First ed. 1979: Cornell University Press, 72, 113-114.
Diwan, A. D. et al, “Current Concepts in Intervertebral Disk Restoration,” Tissue Engineering in Orthopedic Surgery, vol. 31, No. 3, pp. 453-464, Jul. 2000.
Doehring, T.C. et al, “Cyclic Load-Displacement Characteristics of Lumber Functional Spinal Units,” 46thAnnual Meeting, Orthopaedic Research Society, Mar. 12-15, 2000.
Elias, H.G., “Theta Solvents,” Brandrup, J. and E. H. Immergut, Polymer Handbook 3rd Ed., John Wiley & Sons, NY 1989.
Flory, P.J., “Principles of Polymer Chemistry,” 1953, Ithaca and London: Cornell University Press.
Gomes, K. et al, “The Effect of Dehydration History on Associating Hydrogels for Nucleus Pulposus Replacement,” Society of Biomaterials, 28thAnnual Meeting Transactions, 2002.
Griffith, S. L. et al, “A Multicenter Retrospective Study of the Clinical Results of the LINK® SB Charité Intervertebral Prosthesis,” SPINE, vol. 19, No. 16, 1842-1849, 1994.
Hassan, C., M., & Peppas, N.A., “Cellular PVA Hydrogels Produced by Freeze/Thawing,” Journal of Applied Polymer Science, vol. 76, 2075-2078 (2000).
Hassan C., M. et al, “Diffusional characteristics of freeze/thawed poly(vinyl alcohol) hydrogels: Applications to protein controlled release from multilaminate devices,” European Journal of Pharmaceutics and Biopharmaceutics 49 (2000) 161-165.
Hassan, C., M. et al., “Modeling of crystal dissolution of poly(vinyl alcohol) gels produced by freezing/thawing process,” Polymer 41 (2000) 6729-6739.
Hassan C. M. & Peppas N. A., “Structure and Morphology of Freeze/Thawed PVA Hydrogels,” Macromolecule, vol. 33, No. 7, 2472-2479, 2000.
Hickey, A. S. & Peppas N.A., “Solute diffusion in poly(vinyl alcohol)/poly(acrylic acid) composite membranes prepared by freezing/thawing techniques,” Polymer, vol. 38 No. 24 1997 5931-5936.
Hong, P. et al, “Effects of Mixed Solvent on Gelation of Poly(vinyl alcohol) Solutions,” Journal of Applied Polymer Science, vol. 79, Issue: 6, Date: Feb. 7, 2001, pp. 1113-1120.
Hong, P, et al, “Solvent Effect on Structural Change of Poly(vinyl alcohol) Physical Gels,” Journal of Applied Polymer Science, vol. 69, 2477-2486 (1998).
Kawanishi K. et al, “Thermodynamic consideration of the sol-gel transition in polymer solutions,” 35thAnnual Meeting of the Society of Polymer Science, Japan, 1986.
Li, J. K., et al, “Poly(vinyl alcohol) nanoparticles prepared by freezing-thawing process for protein/peptide drug delivery,” Journal of Controlled Release 56 (1998) 117-126.
Lozinskii V. I. & Savina I. N., “Study of Cryostructuring of Polymer Systems: 22. Composite Poly(vinyl alcohol) Cryogels Filled with Dispersed Particles of Various Degrees of Hydrophilicity/Hydrophobicity,” Colloid Journal, vol. 64, No. 3, 2002, 336-343.
Lozinsky, V. I., et al, “Study of Cryostructuration of Polymer Systems, XIV. Poly(vinyl alcohol) Cryogels: Apparent Yield of the Freeze-Thaw-Induced Gelation of Concentrated Aqueous Solutions of the Polymer,” Journal of Applied Polymer Science, vol. 77, 1822-1831 (2000).
Lozinsky, V. I. & Damshkaln L. G., “Study of Cryostructuration of Polymer Systems. XVII. Poly(vinyl alcohol) Cryogels: Dynamics of the Cryotropic Gel Formation,” Journal of App
Braithwaite Gavin J. C.
Ruberti Jeffrey W.
Cambridge Polymer Group, Inc.
Egwim Kelechi C
Proskauer Rose LLP
LandOfFree
Systems and methods for controlling and forming polymer gels does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Systems and methods for controlling and forming polymer gels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for controlling and forming polymer gels will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4111001