Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Thermal applicators
Reexamination Certificate
2005-02-03
2009-12-01
Shay, David (Department: 3769)
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Thermal applicators
Reexamination Certificate
active
07627381
ABSTRACT:
A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
REFERENCES:
patent: 2223447 (1940-12-01), Hathaway
patent: 2249935 (1941-07-01), Birtcher
patent: 2407690 (1946-09-01), Southworth
patent: 2543248 (1951-02-01), Ledeboer et al.
patent: 2556556 (1951-06-01), Schmitt et al.
patent: 2635606 (1953-04-01), Hanway
patent: 2656839 (1953-10-01), Howard
patent: 2698622 (1955-01-01), Martens
patent: 2838672 (1958-06-01), Paust
patent: 3077195 (1963-02-01), Folsche
patent: 3181535 (1965-05-01), Milinowski
patent: 3245408 (1966-04-01), Gonser
patent: 3509465 (1970-04-01), Andre et al.
patent: 3543762 (1970-12-01), Kendall
patent: 3747013 (1973-07-01), Mettler
patent: 3800802 (1974-04-01), Berry et al.
patent: 3991770 (1976-11-01), LeVeen
patent: 4032860 (1977-06-01), LeVeen
patent: 4095602 (1978-06-01), Leveen
patent: 4106488 (1978-08-01), Gordon
patent: 4119102 (1978-10-01), LeVeen
patent: 4121592 (1978-10-01), Whalley
patent: 4140130 (1979-02-01), Storm, III
patent: 4154246 (1979-05-01), LeVeen
patent: 4210152 (1980-07-01), Berry
patent: 4230129 (1980-10-01), LeVeen
patent: 4237898 (1980-12-01), Whalley
patent: 4282887 (1981-08-01), Sterzer
patent: 4285346 (1981-08-01), Armitage
patent: 4303636 (1981-12-01), Gordon
patent: 4325361 (1982-04-01), Harrison
patent: 4356458 (1982-10-01), Armitage
patent: 4392040 (1983-07-01), Rand et al.
patent: 4402309 (1983-09-01), Harrison
patent: 4412540 (1983-11-01), Bentall
patent: 4429698 (1984-02-01), Bentall
patent: 4471787 (1984-09-01), Bentall
patent: RE32057 (1985-12-01), LeVeen
patent: RE32066 (1986-01-01), Leveen
patent: 4587978 (1986-05-01), Suyama et al.
patent: 4595008 (1986-06-01), Guibert
patent: 4667658 (1987-05-01), Guibert
patent: 4667677 (1987-05-01), De Mino et al.
patent: 4674481 (1987-06-01), Boddie et al.
patent: 4679561 (1987-07-01), Doss
patent: 4700179 (1987-10-01), Fancher
patent: 4785829 (1988-11-01), Convert et al.
patent: 4800899 (1989-01-01), Elliott
patent: 4823811 (1989-04-01), Harrison
patent: 4823813 (1989-04-01), Harrison
patent: 4878493 (1989-11-01), Pasternak et al.
patent: 4977380 (1990-12-01), Martin et al.
patent: 4983159 (1991-01-01), Rand
patent: 5003991 (1991-04-01), Takayama et al.
patent: 5010897 (1991-04-01), Leveen
patent: 5057095 (1991-10-01), Fabian
patent: 5099756 (1992-03-01), Franconi et al.
patent: 5099840 (1992-03-01), Goble et al.
patent: 5128147 (1992-07-01), Leveen et al.
patent: 5186181 (1993-02-01), Franconi et al.
patent: 5249575 (1993-10-01), De Mino et al.
patent: 5260050 (1993-11-01), Ranney
patent: 5371342 (1994-12-01), Saitoh
patent: 5386837 (1995-02-01), Sterzer
patent: 5411730 (1995-05-01), Kirpotin et al.
patent: 5478303 (1995-12-01), Foley-Nolan et al.
patent: 5676695 (1997-10-01), De Mino et al.
patent: 5827276 (1998-10-01), LeVeen et al.
patent: 5855576 (1999-01-01), LeVeen et al.
patent: 5868740 (1999-02-01), LeVeen et al.
patent: 5922013 (1999-07-01), Fallik
patent: 5935390 (1999-08-01), Felix et al.
patent: 5983141 (1999-11-01), Sluijter et al.
patent: 6139819 (2000-10-01), Unger et al.
patent: 6165440 (2000-12-01), Esenaliev
patent: 6212432 (2001-04-01), Matsuura
patent: 6240319 (2001-05-01), Rogers
patent: 6424820 (2002-07-01), Burdick et al.
patent: 6424864 (2002-07-01), Matsuura
patent: 6425877 (2002-07-01), Edwards
patent: 6454765 (2002-09-01), Leveen et al.
patent: 6468273 (2002-10-01), Leveen et al.
patent: 6470217 (2002-10-01), Fenn et al.
patent: 6512955 (2003-01-01), McEnany et al.
patent: 6530944 (2003-03-01), West et al.
patent: 6575967 (2003-06-01), Leveen et al.
patent: 6622731 (2003-09-01), Daniel et al.
patent: 6662054 (2003-12-01), Kreindel et al.
patent: 6864755 (2005-03-01), Moore
patent: 6997863 (2006-02-01), Handy et al.
patent: 7005935 (2006-02-01), Moore
patent: 7022105 (2006-04-01), Edwards
patent: 7074175 (2006-07-01), Handy et al.
patent: 7108696 (2006-09-01), Daniel et al.
patent: 7163664 (2007-01-01), Paskalov et al.
patent: 7291314 (2007-11-01), Paskalov et al.
patent: 2002/0026224 (2002-02-01), Thompson et al.
patent: 2002/0045920 (2002-04-01), Thompson
patent: 2003/0195410 (2003-10-01), Winter
patent: 2004/0044385 (2004-03-01), Fenn et al.
patent: 2004/0050682 (2004-03-01), Paskalov et al.
patent: 2004/0059328 (2004-03-01), Daniel et al.
patent: 2004/0069618 (2004-04-01), Paskalov et al.
patent: 2004/0141876 (2004-07-01), Paskalov et al.
patent: 2004/0199070 (2004-10-01), Krockel
patent: 2004/0210282 (2004-10-01), Flock et al.
patent: 2004/0229295 (2004-11-01), Marchitto et al.
patent: 2004/0253181 (2004-12-01), Port et al.
patent: 2005/0056596 (2005-03-01), Paskalov et al.
patent: 2005/0090732 (2005-04-01), Ivkov et al.
patent: 2005/0118102 (2005-06-01), Xiang et al.
patent: 2005/0251233 (2005-11-01), Kanzius
patent: 2005/0251234 (2005-11-01), Kanzius et al.
patent: 2006/0047328 (2006-03-01), Murphy
patent: 2006/0190063 (2006-08-01), Kanzius
patent: 2006/0206180 (2006-09-01), Alcidi
patent: 0 325 456 (1989-07-01), None
patent: 0 713 715 (1996-05-01), None
patent: WO 90/01353 (1990-02-01), None
patent: 91/07132 (1991-05-01), None
patent: WO 2007/027614 (2007-03-01), None
Armitage, D.W., et al., Radiofrequency-induced hyperthermia: computer simulation of specific absorption rate distributions using realistic anatomical models, stacks.iop.org/0013-9155/28/31, Jan. 1983 (Abstract).
Brusentsov, N.A., et al., Hyperthermia of Tumors at 0.88 MHz, Russian Cancer Research RAMS, Radiotechnical Research Institute, Russia, Moscow, Sep. 1999, (Abstract).
Buscarini, L., et al., Laparoscopic ablation of liver adenoma by radiofrequency electrocauthery, Gastrointestinal Endoscopy, vol. 41, No. 1, 1995, pp. 68-70.
Chen, A., et al., Cross-Linking of Cell Surface Receptors Enhances Cooperativity of Molecular Adhesion, Biophysical Journal, vol. 78, Jun. 2000, pp. 2814-2820.
Chen, R.J., et al., Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors, PNAS, Apr. 29, 2003, vol. 100, No. 9, pp. 4984-4989.
Curley, S., et al., Direct Intratumoral Injection of a Novel Collagen Matrix Gel and Cisplatin Effectively Controls Experimental Liver Tumors, Cancer Research, Therapy and Control, 1995, vol. 4, pp. 247-254.
Curley, S., et al., Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients, Annals of Surgery, vol. 239, No. 4, 2004, pp. 450-458.
Curley, S., et al., Radiofrequency Ablation of Epatocellular Cancer in 110 Patients with Cirrhosis, Annals of Surgery, vol. 232, No. 3, Apr. 6-8, 2000, pp. 381-391.
Curley, S., et al., Radiofrequency Ablation of Unresectable Primary and Metastatic Hepatic Malignancies, Annals of Surgery, vol. 230, No. 1, Jul. 1999, pp. 1-8.
Francesco, I., et al., Radiofrequency Ablation in Patients with Primary Breast Carcinoma, Cancer, vol. 92, No. 8, Oct. 15, 2001, pp. 2036-2044.
Freitas, Jr., R.A., 15.3.5.5 Alumina and Sapphire Particles, Nanomedicine, vol. IIA: Biocompatibility, 2003.
Hiraoka, A.M., et al, Multi-institutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (Thermotron RF-8) in combination with radiation for cancer therapy, Cancer, vol.
Kanzius John
Keating Michael J.
McDonald Robert J.
Steinbrink William Harry
Calfee Halter & Griswold LLP
Shay David
Therm Med, LLC
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