Systems and methods for collecting diluted mononuclear cells

Details Systems and methods for collecting diluted mononuclear cells Systems and methods for collecting diluted mononuclear cells

1997-07-01

2000-02-22

Kim, John

Liquid purification or separation

Processes

Separating

210 85, 210 86, 210 97, 210143, 210739, 210744, 494 1, 494 37, B01D 2126

Patent

active

060276576

ABSTRACT:
Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.

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