Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1996-08-20
1998-06-16
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 931, 424 932, 424529, 424534, 4351723, 4353201, 514 44, 935 23, 935 71, A01N 4304, A01N 6300, C12N 516, C12N 1507
Patent
active
057665850
ABSTRACT:
The present invention relates to methods of therapeutic or prophylactic treatment of connective tissue diseases by systemic or local delivery of a nucleic acid sequence to a mammalian host. Expression of the nucleic acid sequence results in the systemic delivery of a biologically active protein or peptide which acts to antagonize inflammatory, hypertrophic and erosive phenomenon associated with connective tissue disease. Systemic delivery of such gene products results in sustained treatment of connective tissue diseases such as rheumatoid arthritis and systemic lupus erythematosus.
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Evans Christopher H.
Robbins Paul D.
Meyers Diane R.
Stanton Brian R.
University of Pittsburgh of the Commonwealth System of Higher Ed
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