Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2008-07-01
2008-07-01
Li, Q. Janice (Department: 1633)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093100, C424S093200
Reexamination Certificate
active
07393526
ABSTRACT:
The present invention relates to the field of cellular and molecular therapy with modified (genetically or growth factor engineered) and unmodified stem cells (SCs). More particularly, the invention relates to a method of systemic treatment of central nervous system (CNS) and other tumors in both intracranial/intraspinal and extracranial/extraspinal sites, using neural stem cells (NSCs), a prototype for solid organ, non-hematopoietic stem cells.
REFERENCES:
patent: 5624830 (1997-04-01), Mullen et al.
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753506 (1998-05-01), Johe
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 6497872 (2002-12-01), Weiss et al.
patent: 6528306 (2003-03-01), Snyder et al.
patent: 6541255 (2003-04-01), Snyder et al.
patent: 6680198 (2004-01-01), Snyder et al.
patent: 6749850 (2004-06-01), Finkelstein et al.
patent: WO 00/20560 (2000-04-01), None
Cowan et al, Clin Cancer Res 1999;5:1619-28.
Garcia-Sanchz et al, Blood 1998;92:672-82.
Zhao et al, Blood 1997;90:4687-98.
Game et al, Wien Klin Wochenschr 2001;113:832-38.
Platt et al, Nat Biotech Mar. 2002;231-2.
Aboody, K.S. et al., “Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas,” Proc. Natl. Acad. Sci. USA, 97:12846-12851, (Nov. 7, 2000).
Benedetti, S. et al., “Gene Therapy of Experimental Brain Tumors Using Neural Progenitor Cells,” Nature Medicine, 6(4):447-450, (Apr. 2000).
Black, P., “Chapter 18: Meningiomas,” Cancer of the Nervous System, Blackwell Scientific Inc. (Boston), p. 349-362. (Nov. 1996).
Brüstle, O., “Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats,” Nature Biotechnology, 16:1040-1044, (Nov. 1998).
Culver, K.W. et al., “In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors,” Science, 256:1550-1552, (Jun. 12, 1992).
Flax, J.D. et al., “Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes,” Nature Biotechnology, 16:1033-1039, (Nov. 1998).
Kramm, C.M. et al., “Gene Therapy for Brain Tumors,” Brain Pathology, 5:345-381, (1995).
Lal, B. et al., “Endothelial cell implantation and survival within experimental gliomas,” Proc. Natl. Acad. Sci. USA, 91:9695-9699, (Oct. 1994).
Ojeifo, J.O. et al., “Angiogenesis-directed Implantation of Genetically Modified Endothelial Cells in Mice,” Cancer Research, 55:2240-2244, (Jun. 1, 1995).
Short, M.P. et al., “Rapid Communication Gene Delivery to Glioma Cells in Rat Brain by Grafting of a Retrovirus Packaging Cell Line,” Journal of Neuroscience Research, 27:427-439, (1990).
Snyder, E.Y. et al., “Multipotent Neural Progenitor or Stem-like Cells May Be Uniquely Suited for Therapy for Some Neurodegenerative Conditions,” Clinical Neuroscience, 3:310-316, (1996).
Svendsen, C.N., “Review Article: Neural Stem Cells for Brain Repair,” Alzheimer's Research, 3(4):131-135, (Aug. 1997).
Tamura, M. et al., “Targeted Killing of Migrating Glioma Cells by Injection of HTK-Modified Glioma Cells,” Human Gene Therapy, 8:381-391, (Mar. 1, 1997).
Noble, M., “Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providng a means fo repairing tumor associated damage?,” Proc. Natl. Acad. Sci. USA , 97(23):12393-12395, (Nov. 7, 2000).
Aboody Karen S.
Breakefield Xandra O.
Brown Alice B.
Snyder Evan Y.
Children's Medical Center Corporation
Li Q. Janice
Nixon & Peabody LLP
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