Systemic formulations containing beta-carotene and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S703000, C514S725000

Reexamination Certificate

active

06878747

ABSTRACT:
Disclosed herein are systemic formulations comprising beta-carotene and a solubilizer selected from tetrahydrofuran (THF), polyethylene glycol (PEG), and mixtures thereof. Generally, the formulations are administered to animals in need thereof in therapeutically effective amounts of beta-carotene for the purpose intended. The solubilizers greatly enhance the bioavailability of beta-carotene administered systemically. Another embodiment of the present invention is a method for administering beta-carotene to an animal in need thereof by administering the formulation of the present invention. Yet another embodiment is a method for treating an animal in need thereof by administering a therapeutically effective amount of the formulation of the present invention. The invention includes a method for treating an animal suffering from or susceptible to sepsis by administering an effective amount for treating sepsis of the formulation of the present invention.

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HCAPLUS Abstract, AN 1993:595198 Cooney et al., Methodsin Enzymology (1993), 214 (Carotenoids, Pt. B), 55-68.*
Database HCAPLUS on ACS No. 2000:419783, Kim et al. Controlled Release of All-Trans-Retinoic Acid from PEGylated Gelatin Nanoparticles By Enzymatic Degradation. Abstract, 1999, 4 (3), pp. 215-218.
Database HCAPLUS on ACS No. 1998:253034, Bausch et al. Process for the Manufacture of A Powderey Preparation. WO 9816204A1 Apr. 23, 1998.
Database HCAPLUS on ACS No. 1993:595198, Cooney et al. Solubilization, Cellular Uptake, and Activity of Beta-Carotene and Other Carotenoids as Inhibitors of Neoplastic Transformation in Cultured Cells. Method Enzymol. 1993, vol. 214, pp. 55-68.

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