Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-12-14
1996-09-10
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424426, 424428, 424430, 424434, 424435, 424436, 424437, 424464, 424469, 424499, 5147723, 514777, 514778, A61K 950, A61K 914, A61K 920, A61K 4736
Patent
active
055543880
ABSTRACT:
A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the pharmacologically active compound is preferably insulin or calcitonin. The composition may be a solution, dispersion, powder or microspheres. Other enhancers, such as lysophosphatidylcholine, can be included if desired.
REFERENCES:
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patent: 4946870 (1990-08-01), Partain, III et al.
Biol. Abs. 75074688 (Sawayanagi et al., 1982, Chem. & Pharm. Bull., "Directly Compressed Tablets containing Chitin or Chitosan in Addition to Mannitol", vol. 30 (11) pp. 4216-4218).
Chem. Abs. 112:84024c, vol. 112, 1990, (Manosroi et al., Drug Dev. Ind. Pharm., 15 (14-16), 2531-2546, "The Entrapment of a Human Insulin-DEAE Dextran Complex in Different Compound Liposomes", (1989)).
Davis et al., Delivery Systems for Peptide Drugs, Plenum Press, New York, (1987).
Sawayanagi et al., Chem. Pharm. Bull., 31, 2062-2068 (1983).
Society for Experimental Biology, 24-29, Jul. 1988 "Mucas and Related Topics:".
T. Igawa et al., Chem. Pharm Bull, vol. 36, No. 8 pp. 3055-3059 (1988) "Enzyme Immunoassay of Human Fibroblast Interferon after Intranasal Administration with Several Excipients in Rabbits".
Y. Maitani, et al., "Influence of molecular weight and charge on nasal absorption of dextran and DAEA-dextran in rabbits", Int. J. Pharm., vol. 49, pp. 23-27 (1989).
Davis, et al., Delivery Systems for Peptide Drugs, Plenum Press, New York, (1987).
Sawayanagi et al., "Dissolution Properties and Bioavailability of Phenytoin from Ground Mixtures with Chitin or Chitosan", Chem. Pharm. Bull vol. 31 pp. 2062-2068, (1983).
Anderson, M. T., et al., oral presentation at a meeting of the Society for Experimental Biology, Jul. 24-29, 1988, Manchester, U.K. "Mucas and Related Topics".
Azpuru Carlos A.
Danbiosyst UK Limited
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