Systemic administration of a therapeutic preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 3, 530303, A61K 3828, C07K 1462

Patent

active

055062032

ABSTRACT:
A method of treating a patient in need of insulin treatment, including the steps of introducing into the lower respiratory tract of the patient an effective amount of a therapeutic preparation in the form of a dry powder containing (a) insulin and (b) an enhancer compound which enhances the absorption of insulin in the lungs of the patient.

REFERENCES:
patent: 4524769 (1985-06-01), Wetterlin
patent: 4534345 (1985-08-01), Wetterlin
patent: 4548922 (1985-10-01), Carey et al.
patent: 4668218 (1987-05-01), Virtanen
patent: 4746508 (1988-05-01), Carey et al.
patent: 4759358 (1988-09-01), Carey et al.
patent: 4907583 (1990-03-01), Wetterlin et al.
Allenby et al., The Absorption of Insulin Across the Respiratory Tract of the Guinea-Pig (U), The Aerosol Society, Fourth Annual Conference 1990, pp. 129-134.
Aungust and Rogers, Comparison of the Effects of Various Transmucosal Absorption Promotors on Buccal Insulin Delivery, Int. J. Pharm. (Netherlands), 1989, 53/3, 227-235.
Bjork, Starch Microspheres as a Nasal Delivery System for Drugs, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 103, 1993.
Bjork and Edman, Degradable Starch Microspheres as a Nasal Delivery System for Insulin, Int. J. Pharm. 47:233-238, 1988.
Brange et al., Monomeric Insulins and Their Experimental and Clinical Implications, Diabetes Care 13:923-954, 1990.
Edman and Bjork, Routes of Delivery: Case Studies, Advanced Drug Delivery Reviews 8:165-177, 1992.
Igawa et al., Effect of Absorption Promoters in Intranasal Administration of Human Fibroblast Interferon as a Powder Dosage Form in Rabbits, Chem. Pharm. Bull. 37:418-421, 1989.
Komada et al., Intratracheal Delivery of Peptide and Protein Agents: Absorption from Solution and Dry Powder by Rat Lung, J. Pharm. Sci. 83:863-867, 1994.
Lasker, The Diabetes Control and Complications Trail, N. Engl. J. Med. 329:1035-1036, 1993.
Laube et al., Preliminary Study of the Efficacy of Insulin Aerosol Delivery by Oral Inhalation in Diabetic Patients, JAMA 269:2106-2109, 1993.
Lee et al., Intranasal Bioavailability of Insulin Powder Formulations: Effect of Permeation Enhancer-to-Protein Ratio, J. Pharm. Sci. 80:725-729, 1991.
Mishima et al., Studies on the Promoting Effects of Medium Chain Fatty Acid Salts on the Nasal Absorption of Insulin in Rats, J. Pharma -Dyn. 10:624-631, 1987.
Morita et al., Effects of Various Absorption Promoters on Pulmonary Absorption of Drugs with Different Molecular Weights, Biol. Pharm. Bull. 16:269:262, 1993.
Nagai et al., Powder Dosage Form of Insulin for Nasal Administration, J. Controlled Release 1:15-22, 1984.
"Diabetes Mellitus", Ch. VI in Scientific American Medicine, Scientific American, Inc., Apr. 1993.
The Diabetes Control and Complications Trail Research Group, The Effect of Intensive Treatment of Diabetes on the Development . . . Complications in Insulin-Dependent Diabetes Mellitus, N. Engl. J. Med. 329:977-86, 1993.
Pontiroli et al., Nasal Administration of Glucagon and Human Calcitonin to Healthy Subjects: a Comparison of Powders and Spray Solutions and of Different Enhancing Agents, Eur. J. Clin. Pharmcol. 37:427-430, 1989.
Schipper et al., Nasal Insulin Delivery with Dimethyl-.beta.-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations, Pharmaceutical Research 10:682-686, 1993.
Selam and Charles, Devices for Insulin Administration, Diabetes Care 13:955-979, 1990.
Touitou and Rubenstein, Targeted Enteral Delivery of Insulin to Rats, Int. J. Pharm. (Amst.), 30(2-3), 1986, 95-100.
Wigley et al., Insulin Across Respiratory Mucosae by Aerosol Delivery, Diabetes 20:552-556, 1971.
Zinman, Medical Intelligence--The Physiologic Replacement of Insulin, W. Engl. J. Med. 321:363-370, 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Systemic administration of a therapeutic preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Systemic administration of a therapeutic preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systemic administration of a therapeutic preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-138936

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.