Systematic polypeptide evolution by reverse translation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435691, 4351721, 4351723, 935 3, 935 4, 935 10, 935 17, C12P 2102, C12N 1500

Patent

active

058437010

ABSTRACT:
A method for preparing polypeptide ligands of target molecules wherein candidate mixtures comprised of ribosome complexes or mRNA.multidot.polypeptide copolymers are partitioned relative to their affinity to the target and amplified to create a new candidate mixture enriched in ribosome complexes or mRNA.multidot.polypeptide copolymers with an affinity to the target.

REFERENCES:
patent: 5658754 (1997-08-01), Kawasaki et al.
Krisch et al. Nucleotide sequences involved in bacteriophage T4 gene 32 translational self regulation. Proc. Nat. cad. Sci. USA 79:4937-4941, Aug. 1982.
Formosa et al. Affinity purification of bacteriophage T4 proteins essential for DNA replication ad genetic recombination. Proc. Nat. Acad. Sci., USA 80: 2442-2446, May 1983.
Krassa et al. Protein-protei interactions with the acidic COOH terminus of the single stranded DnA binding protein of the bacteriophage T4, May 1991.
Joyce (1989) Gene 82:83.
Joyce & Inoue (1989) Nucleic Acids Research 17:711.
Ellington & Szostak (1990) Abstracts of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 84.
Kinzler & Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn & Spiegelman (1969) PNAS USA 63:805.
Levisohn & Spiegelman (1968) PNAS USA 60-866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant & Struhl (1988) Nucleic Acids Reseach 16:7673.
Oliphant & Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson & Joyce (1990) Nature 344:467.
Thiesen & Bach (1990) Nucleic Acids Research 18:3203.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Systematic polypeptide evolution by reverse translation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Systematic polypeptide evolution by reverse translation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systematic polypeptide evolution by reverse translation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2394889

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.