Systematic evolution of ligands by exponential enrichment: chemi

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 912, 935 77, 935 78, C12P 1934, C12Q 168

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active

057053375

ABSTRACT:
This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.

REFERENCES:
patent: 4959309 (1990-09-01), Dattagupta et al.
patent: 5270163 (1993-12-01), Gold et al.
Bartel and Szostak (1993) Science 261:1411.
Beaudry and Joyce (1992) Science 257:635.
Cech (1987) Science 236:1532.
Crouch and Eaton (1994) Nucleosides & Nucleotides 13:939.
Lorsch and Szostak (1994) Nature 371:31.
McCorkle and Altman (1987) Concepts Biochem. 64:221.
Pan and Uhlenbeck (1992) Biochemistry 31:3887.
Piccirilli et al. (1992) Science 256:1420.
Prudent et al. (1994) Science 264:1924.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Oleksyszyn and Powers (1991) Biochemistry 30:485.
Oleksyszyn and Powers (1989) Biochemical and Biophysical Research Communications 161:143.
Simon et al. (1988) Adv. Exp. Med. Biol. 240:65.
Simon et al. (1988) Exp. Lung Res. 14:85.
Vered et al. (1988) Exp. Lung Res. 14:67.

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