Systematic evolution of ligands by exponential enrichment: Chemi

Details Systematic evolution of ligands by exponential enrichment: Chemi Systematic evolution of ligands by exponential enrichment: Chemi

1995-06-05

1998-06-09

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 912, 536 254, C07H 2102, C07H 2104, C12P 1934, C12Q 168

Patent

active

057635951

ABSTRACT:
This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.

REFERENCES:
patent: 4808520 (1989-02-01), Dattagupta et al.
patent: 4959309 (1990-09-01), Dattagupta
patent: 5270163 (1993-12-01), Gold et al.
Church et al., PNAS USA 81:1991-1995 (Apr. 1984).
Smith et al., Nuc. Acids Res. 13(7):2399-2412 (1985).

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