Systematic evolution of ligands by exponential enrichment: chemi

Details Systematic evolution of ligands by exponential enrichment: chemi Systematic evolution of ligands by exponential enrichment: chemi

1997-08-21

1999-12-07

Ztonmer, Stephanie

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 243, 536 254, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C07H 2102

Patent

active

059981423

ABSTRACT:
This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.

REFERENCES:
patent: 4959309 (1990-09-01), Dattagupta et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5763177 (1998-06-01), Gold et al.
patent: 5763595 (1998-06-01), Gold et al.

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