Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-11-22
2005-11-22
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S003100
Reexamination Certificate
active
06967191
ABSTRACT:
The present invention is a system capable of increasing retinal and neural glucose oxidation by enhancing pyruvate dehydrogenase activity and therefore treats retinopathy and central nervous system disorders in both diabetic and non-diabetic patients. The current invention is a system of the treating of eye and nerve diseases using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in retinal and neural glucose oxidation by enhancing pryuvate dehydrogenase activity, therefore treating retinopathy and central nervous system disorders in both diabetic and non-diabetic patients.
REFERENCES:
patent: 4826810 (1989-05-01), Aoki
Aoki, T. et al., “Chronic Intermittent Intravenous Insulin Therapy: A New Frontier in Diabetes Therapy”, Diabetes Technology & Therapeutics, vol. 3, No. 1, 2001: 111-123.
Aoki, T. et al., “Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus”, The Lancet, vol. 342, Aug. 28, 1993: 515-518.
Aoki Diabetes Research Institute, “CIIIT Treatment Results”, Mar. 31, 2001.
Heinemann, L. et al., “Pulsatile insulin infusion and glucose homeostasis in well-controlled Type 1 (insulin-dependent) diabetic patients”, J of Int Med, 1989, 226: 325-30.
Aoki, T. et al., “Effect of intensive insulin therapy on progression of overt nephropathy in Patients with type 1 diabetes mellitus”, Endocrine Practice, vol. 5, No. 4, Jul./Aug. 1999; 174-178.
Campell Bruce R.
Masamori Eric G.
Teller Roy
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