System for the controlled release of active agents and a process

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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424468, 6048901, 6048921, A61K 924

Patent

active

058403353

ABSTRACT:
A system for the controlled release of an active agent to an environment of use, said system having a predetermined release rate of the active agent to the environment of use, comprising: a) a shell comprised of a wall formed of a water-insoluble material which is permeable to the passage of an external fluid, and b) a core which is surrounded by said shell, said core comprised of i) a water-soluble active agent, and ii) a soluble polymeric adjuvant capable of unlimited swelling.

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The Controlled Porosity Osmotic Pump, Gaylen M. Zentner, et al, Journal of Controlled Release, 1 (1985) pp. 269-282.

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