System for selective release of liposome encapsulated material v

Details System for selective release of liposome encapsulated material v System for selective release of liposome encapsulated material v

1987-05-28

1990-01-02

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

606 2, A61M 130

Patent

active

048910430

ABSTRACT:
A system for selectively releasing materials, such as drugs or dyes, at a specific site in the body of an animal. The system uses laser radiation to rupture laser light-absorbing and heat-sensitive lipid vesicles containing the drugs or dyes, thereby releasing these materials at the specific site irradiated by the laser. By using this system, the location and concentration of the materials are controlled as well as the duration of the materials' release and the release can be triggered repetitively. The laser beam used is visible or its location can be made visible to the naked eye so that the location and size of the beam's contact with the irradiated tissue can be observed and adjusted.

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Yatvin et al., "Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia," Science, vol. 202, pp. 1290-1292, Dec. 22, 1978.
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