System for processing an organ preparatory to transplant

Details System for processing an organ preparatory to transplant System for processing an organ preparatory to transplant

1982-11-10

1984-09-25

Warden, Robert J.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

435287, A01N 102, C12M 100

Patent

active

044736371

ABSTRACT:
A system for processing an organ such as a kidney so as to render it suitable for storage, shipment and eventual transplantation. After its removal from a donor, the organ is cradled in a net suspended within a basin. A preservative fluid initially at normal blood temperatures progressively cooled to avoid thermal shock, the fluid being pumped through the organ to flush out its natural fluids. The pumping action is such as to simulate that of the heart and its associated circulatory system. The exterior of the organ is chilled by simultaneously introducing the preservative fluid into the basin. After this chilling procedure is completed, the cradle carrying the cooled organ is transferred to a basin disposed in a thermally-insulated shipping box which is then filled with chilled preservative fluid and maintained at a desired low temperature level by an associated refrigeration unit. Just prior to transplantation, the cradle carrying the organ is removed from the box and the organ is again flushed, using the same procedure as in chilling but in reverse, the preservative fluid being raised to a temperature level close to normal blood temperature. Upon completion of this procedure, the organ is in condition for transplantation.

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