Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1997-06-16
2000-07-25
McDermott, Corrine
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
600365, A61M 3100
Patent
active
060931671
ABSTRACT:
There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.
REFERENCES:
patent: 4003379 (1977-01-01), Ellinwood, Jr.
patent: 4403984 (1983-09-01), Ash et al.
patent: 4431004 (1984-02-01), Bessman et al.
patent: 4704029 (1987-11-01), Van Heuvelen
patent: 5101814 (1992-04-01), Palti
patent: 5113859 (1992-05-01), Funke
patent: 5165407 (1992-11-01), Wilson et al.
patent: 5190041 (1993-03-01), Palti
patent: 5231988 (1993-08-01), Wernicke et al.
patent: 5362307 (1994-11-01), Guy et al.
"Kinetics of Intraperitoneally Infused Insulin in Rats--Functional Implications for the Bioartificial Pancreas"--Paul De Vos et al. (Diabetes, vol. 45, Aug. 1996).
"Pancreatic B Cells Are Bursting, But How?"--Daniel L. Cook et al. (TINS, vol. 14, No. 9, 1991).
Houben Richard P. M.
Renirie Alexis C. M.
Weijand Koen J.
Jaro Michael J.
McDermott Corrine
Medtronic Inc.
Patton Harold
Woods Thomas F.
LandOfFree
System for pancreatic stimulation and glucose measurement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System for pancreatic stimulation and glucose measurement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System for pancreatic stimulation and glucose measurement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1333252