Chemical apparatus and process disinfecting – deodorizing – preser – Chemical reactor – Organic polymerization
Patent
1995-06-07
1998-02-03
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Chemical reactor
Organic polymerization
422130, 422196, 4353041, 4353052, 530333, 530334, 935 88, B01J 1900, B01J 800, C12M 100, C07K 1700
Patent
active
057141274
ABSTRACT:
A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.
REFERENCES:
patent: 3192184 (1965-06-01), Brill et al.
patent: 3379315 (1968-04-01), Broadwin
patent: 3518164 (1970-06-01), Andelin et al.
patent: 3752651 (1973-08-01), Bush
patent: 3905482 (1975-09-01), Knulst
patent: 3918920 (1975-11-01), Barber
patent: 4304865 (1981-12-01), O'Brien et al.
patent: 4495150 (1985-01-01), Cook et al.
patent: 4511534 (1985-04-01), Bennett, Jr. et al.
patent: 4597946 (1986-07-01), Ward
patent: 4689405 (1987-08-01), Frank et al.
patent: 4787988 (1988-11-01), Bertoncini et al.
patent: 4929427 (1990-05-01), Guala
patent: 4929798 (1990-05-01), de Lasa
patent: 4992544 (1991-02-01), Miller
patent: 5049507 (1991-09-01), Hawke et al.
patent: 5053454 (1991-10-01), Judd
patent: 5133939 (1992-07-01), Mahe
patent: 5147608 (1992-09-01), Hudson et al.
patent: 5177060 (1993-01-01), Wei
patent: 5186898 (1993-02-01), Bridgham et al.
patent: 5260872 (1993-11-01), Copeland et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5417922 (1995-05-01), Markin et al.
Peptides--Chemistry, Structure and Biology, "Automated Multiple Peptide Synthesis With BOP Activation", by H. Gausepohl et al.; pp. 1003-1004; Jul. 1990.
Vol. 45, No. 24, "Fully Automatic Simultaneous Multiple Peptide Synthesis in Micromolar Scale etc." by G. Schnorrenberg et al.; pp. 7759-7764; 1989.
J. Am. Chem. Soc., 1992, 114, pp. 10997-10998, "A General and Expedient Method for the Solid-Phase Synthesis of 1,4-Benzodiazepine Derivatives", by B. Bunin et al.
DeWitt Sheila H. H.
Kiely John S.
Pavia Michael R.
Schroeder Mel C.
Stankovic Charles J.
Almer Charles W.
Dawson E. Leigh
Tinney Francis J.
Warden Robert J.
Warner-Lambert & Company
LandOfFree
System for multiple simultaneous synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System for multiple simultaneous synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System for multiple simultaneous synthesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-659791