System for minimizing native fiber fluorescence variations in fi

Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation

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2504581, 2504591, G01J 330

Patent

active

054852692

ABSTRACT:
An optical system for minimizing native fluorescence variations from a fiber optic laser induced fluorescence sensor comprises a fiber probe for receiving excitation light which is capable of guiding excitation light to an analyte and coupling fluorescence from the analyte to a detector and an excitation light director for selectively supplying the excitation light to the fiber probe during a plurality of predetermined measurement periods. The excitation light director includes a light source which may itself be programmable or a light source in combination with a programmable shutter or beam deflector.

REFERENCES:
patent: 4648892 (1987-03-01), Kittrell et al.
patent: 4929561 (1990-05-01), Hirschfeld
patent: 4945245 (1990-07-01), Levin
patent: 5061857 (1991-10-01), Thompson et al.
patent: 5084617 (1992-01-01), Gergely
patent: 5315993 (1994-05-01), Alcala
"Comparative Analysis of Toxin Detection in Biological and Environmental Samples" by Ogert, et al, SPIE Vol. 2068, pp. 151-158.
"Fiber-Optic Chemical Sensors for Competitive Binding Fluoroimmunoassay" by Tromberg, et al, Anal. Chem. 1987, vol. 59, pp. 1226-1230.

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