Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1993-11-24
1995-01-03
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 2726, G01N 27447
Patent
active
053783344
ABSTRACT:
An electrophoretic or chromatographic separation capillary containing a fluid or gel defines a bore therein through which a sample migrates and separates into components. The tube has a side wall defining a passage therein. A substance is introduced into the capillary through the pasage by means of gravity, pressure or electroosmosis. The substance introduced changes the electroosmotic flow rate of the fluid in the capillary tube. The electroosmotic flow rate of the fluid in the capillary tube can be monitored by introducing a compound through the passage and detecting the concentration of the compound. Information on the flow rate can be used in a feedback action to control the flow rate, such as to keep it constant.
REFERENCES:
patent: 4165219 (1979-08-01), Huber
patent: 4859301 (1989-08-01), Brenner et al.
patent: 5069766 (1991-12-01), Zhu et al.
patent: 5180479 (1993-01-01), Rose, Jr.
B. J. Wanders et al "Methods for On-Line Determination and Control of Electroendosmosis in Capillary Electrochromatography and Electrophoresis" Journal of Chromatography 470 (1989) 89-93.
F. M. Everaerts et al "Feasibility of capillary zone electrophoresis with suppression of electroendosmotic flow in completely closed systems" Journal of Chromatography 503 (1990) 245-255.
Edward S. Yeung, "Self-Regulating Dynamic Control of Electroosmotic Flow in Capillary Electrophoresis" Analytical Chemistry 65 (1993) 650-652.
"On-Column Sample Concentration Using Field Amplification in CZE," by Chien et al., Analytical Chemistry, vol. 64, No. 8, pp. 489-496, Apr. 15, 1992.
"Post-Capillary Fluorescence Detection in Capillary Zone Electrophoresis Using o-phthaldialdehyde," by Rose, Jr. et al., Journal of Chromatography, vol. 447, pp. 117-131, 1988.
"Feasibility of Capillary Zone Electrophoresis with . . . ," by Verheggen et al., Journal of Chromatography, vol. 503, pp. 245-255, 1990.
"Self-Regulating Dynamic Control of Electroosmotic Flow . . . ," by Chang et al., Analytical Chemistry, vol. 65, pp. 650-652, 1993.
"Fluorescence Detection in Capillary Zone Electrophoresis . . . ," by Sweedler et al., Analytical Chemistry, vol. 63, pp. 496-502, 1991.
"Capillary Zone Electrophoretic Separation of Peptides and . . . ," by McCormick, Analytical Chemistry, vol. 60, pp. 2322-2328, 1988.
"Rapid Separation of DNA Restriction Fragments Using . . . ," by Cohen et al., Journal of Chromatography, vol. 458, pp. 323-333, 1988.
"Influence of Borate Complexation on the Electrophoretic . . . ," by Hoffstetter-Kuhn et al., Analytical Chemistry, vol. 63, pp. 1541-1547, 1991.
"On-Column Conductivity Detector for Capillary Zone . . . ," by Huang et al., Analytical Chemistry, vol. 59, No. 23, pp. 2747-2749, 1987.
"Zone Electrophoresis in Open-Tubular Glass Capillaries," by Jorgenson et al., Analytical Chemistry, vol. 53, pp. 1298-1302, 1981.
"Capillary Zone Electrophoresis of Proteins in Untreated . . . ," by Lauer et al., Analytical Chemistry, vol. 58, pp. 166-170, 1986.
"High Voltage Capillary Zone Electrophoresis: Operating . . . ," by Altria et al., Chromatographia, vol. 24, pp. 527-532, 1987.
"Current-Monitoring Method for Measuring the Electroosmotic Flow . . . ," by Huang et al., Analytical Chemistry, vol. 60, pp. 1 1837-1838, 1988.
"On-Line Connector for Microcolumns: Application to the On-Column . . . ," by Pentoney, Jr. et al., Analytical Chemistry, vol. 60, pp. 2625-2629, 1988.
"Factors Affecting Direct Control of Electroosmosis Using an . . . ," by Lee et al., Analytical Chemistry, vol. 63, pp. 1519-1523, 1991.
"Laser-Induced Fluorescence Detection in Capillary Zone Electrophoresis," by Nickerson et al., Chapel Hill, N.C.
Dadoo Rajeev
Lee Thomas T.
Zare Richard N.
Niebling John
Starsiak Jr. John S.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
System for measuring and controlling electroosmosis in separatio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System for measuring and controlling electroosmosis in separatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System for measuring and controlling electroosmosis in separatio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2208973