System for interfacing capillary zone electrophoresis and induct

Details System for interfacing capillary zone electrophoresis and induct System for interfacing capillary zone electrophoresis and induct

1995-02-21

1997-01-28

Bell, Bruce F.

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

204452, 250288, G01N 2726, G01N 27447, H01J 4904

Patent

active

055974678

ABSTRACT:
A system for interfacing Capillary Zone Electrophoresis (CZE) systems to Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) sample analysis systems is disclosed. The interface system includes a Sample Introduction Electrophoresis Capillary Tube as an integral part of a modified Direct Injection Nebulizer (DIN) system. During use sample components separated by (CZE) are entered to the modified (DIN) via a sample introduction electrophoresis capillary tube present therein, in which modified (DIN) they are mixed with an entered make-up liquid. The make-up liquid is conductive and serves to make electrophoresis effecting electrical contact to the end of the sample introduction electrophoresis capillary tube in the modified (DIN). The resulting mixture of make-up liquid and separated sample components is nebulized by simultaneous ejection of concentric sample component and make-up liquid mixture and an entered gas flow, to provide a multiplicity of small diameter droplets which are typically injected into an Inductively Coupled Plasma Torch for ionization, prior to entry of resulting ionized sample components to a Mass Spectrometer sample analysis system for detection and analysis thereof. It is noted that the presence of the make-up liquid buffers the effect of the entered nebulizing gas flow upon the capillary zone electrophoresis process, thereby allowing decoupled separate optimization of sample separation and nebulizing processes.

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Zone Electrophoresis in Open-Tubular Glass Capillaries, Jorganson & Lukacs, Anal. Chem., vol. 53, Jan. 1981.
Capillary Electrophoresis Inductively Coupled Plasma Spectrometer for Rapid Elemental Speciation, Olesik, Kinzer, Olesik, Anal. Chem., vol. 67, Jan. 1995.

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