System for in vitro assay for mutagenicity and/or carcinogenicit

Details System for in vitro assay for mutagenicity and/or carcinogenicit System for in vitro assay for mutagenicity and/or carcinogenicit

1976-07-30

1978-02-07

Tanenholtz, Alvin E.

Textiles: fiber preparation

195 28N, C12K 100

Patent

active

040725740

ABSTRACT:
This involves an in vitro assay system to screen for mutagenic and/or carcinogenic agents based on alterations in the fidelity of DNA synthesis. In the system, chemicals will be tested for their mutagenicity or carcinogenicity by measuring increases in the number of mistakes incorporated by purified DNA polymerases using synthetic polynucleotide templates. This system offers the advantage of performing this analysis in the test tube so that all parameters in the reaction can be monitored. Agents that enhance misincorporation during DNA synthesis would be predicted to have a higher probability of being mutagens or carcinogens in the human population.

REFERENCES:
patent: 3816263 (1974-06-01), Rabin et al.
patent: 3850749 (1974-11-01), Kaufmann et al.

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