Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1992-12-15
1996-08-27
Warden, Robert J.
Chemistry: analytical and immunological testing
Biological cellular material tested
422 681, 209564, 209 31, 209579, 209906, B07C 504, B07C 5342, G01N 1500
Patent
active
055500587
ABSTRACT:
This invention relates to a method and apparatus for flexibly controlling sorting decisions for a flow cytometer or similar instrument at a purity vs. yield ratio of sorted particles, particularly at high event rates. The system monitors distances between sequential objects to determine if they are in close enough proximity to be within a single resolution unit of the sorting device. The "friend" or "foe" status of neighboring events is considered by this system in dealing with detected "coincident" events. The system operates on information of the desirability to sort the object, i.e. droplet, based upon the properties of the individual object. A storage and retrieval method is provided for making the information available at the time a sort operation based on a sorting logic condition is performed. Accordingly, an easily reconfigurable mode of operation control is provided to allow customized sorting strategies, based on the needs of individual applications or experiments. This system may be included as an integral part of a flow cytometer/cell sorter or similar instrument and may also be provided as an outboard module to such systems.
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Corio Mark A.
Leary James F.
Pyon Harold Y.
University of Rochester
Warden Robert J.
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