Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1996-05-29
1997-07-01
Millin, Vincent
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820312, 12820323, A61M 1500
Patent
active
056427280
ABSTRACT:
A method is provided for dispensing a clinically effective dose of an inhalable, pharmaceutically active compound. The method includes providing a dry powder inhaler containing a powder including the pharmaceutically active compound, and administering to a patient a dose of the compound that is less than 70% of the dose that would be necessary to obtain a physiologically equivalent result were the compound administered by a pressurized metered dose inhaler. The pharmaceutically active compound is in the form of primary particles at least 80% of which have a particle size of less than 10 microns, and the primary particles are provided as agglomerates which are deagglomerated during inhalation so that at least 40% of the dose administered is in the form of primary particles.
REFERENCES:
patent: 4143658 (1979-03-01), Rambosek et al.
patent: 4524769 (1985-06-01), Wetterlin
patent: 4534345 (1985-08-01), Wetterlin
patent: 4570630 (1986-02-01), Elliott et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4667668 (1987-05-01), Wetterlin
patent: 4668218 (1987-05-01), Virtanen
patent: 4907583 (1990-03-01), Wetterlin et al.
patent: 4973582 (1990-11-01), Yoshida et al.
patent: 5161524 (1992-11-01), Evans
patent: 5190029 (1993-03-01), Byron et al.
patent: 5204113 (1993-04-01), Hartley et al.
patent: 5327883 (1994-07-01), Williams et al.
patent: 5341800 (1994-08-01), Clark et al.
patent: 5349947 (1994-09-01), Newhouse et al.
Murray, John F. et al., "Textbook of Respiratory Medicine," vol. 1, 2d ed., pp.362-3 (W.B. Saunders Co., Phila., 1988, 1994).
Earle B. Weiss et al., Brochial Asthma: mechanisms and therapueitcs,Little, Brown & Co. (Boston: 1985, 1993), pp. 727-729.
Borgstrom, A Possible New Approach of Comparing Different Inhalers and Inhaled Substances, J. Aerosol. Med. 5:298, 1992.
Thorsson et al., Lung Deposition of Budesonide from Turbuhaler is Twice that from a Pressurized Metered Dose Inhaler (pMDI), Poster presented at the British Thoracic Society Winter Meeting, London, UK, Dec. 9-11, 1992.
Bogaard et al., Dose-effect Relationship of Terbutaline Using a Multi-dose Powder Inhalation System (`Turbuhaler`) . . . Powder Inhalation (`Rotahaler`) in Asthmatics, Pharmatherapeutica 5:400-406, 1989.
Tukiainen and Terho, Comparison of Inhaled Salbutamol Powder and Aerosol in Asthmatic Patients with Low Peak Expiratory Flow Level, Eur. J. Clin. Pharamcol. 27:645-647, 1985.
Zainudin et al., Comparison of Bronchodilator Responses and Deposition Patterns of Salbutamol Inhaled from a Pressurised . . . Dose Inhaler, as a Dry Powder, and as a Nebulised Solution, Thorax 45:469-473, 1990.
PCT Search Report in the corresponding PCT Application No. 9203743-1.
Andersson Jan
Jagfeldt Hans
Trofast Eva
Wetterlin Kjell
AB Astra
Millin Vincent
Raciti Eric P.
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