System for demand-based adminstration of insulin

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

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128632, 604 66, A61B 500, G01N 2726

Patent

active

044039840

ABSTRACT:
A system is disclosed for demand-based administration of insulin which utilizes a change in a physical property of a patient's body fluid as an indicator that a change in the body fluid glucose level has occurred and that an appropriate amount of insulin should be supplied to the patient. Body fluid osmolality or one of its colligative properties are particularly suitable for this purpose. A second sensor for measuring such properties as electrical conductivity may be added to detect changes in osmolality caused by such factors as dehydration. Insulin can be delivered to the patient from an extracorporeal source by means of a dual lumen catheter. One lumen of the catheter provides a passageway for the insulin dose and the other lumen provides a passageway through which a replaceable sensors can be introduced into or removed from the patient's body. In the alternative, the entire insulin administration system can be implanted into the patient.

REFERENCES:
patent: 4240438 (1980-12-01), Updike et al.
Guyton et al., Develop. of Implant Electochem Glucose Sensor, Report from Path Dept. Harvard Med School.
Chang et al., Validation and Bioeng. Aspects of an Implantable Glucose Sensor, Trans. Soc. Artif. Int Organs, 1973.
Scientific Tables, Dist. by Geigy Pharmaceuticals, 7th Ed., Documenta Geigy, Ardsley, N.Y.

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