System for controlled release of antiarrhythmic agents

Details System for controlled release of antiarrhythmic agents System for controlled release of antiarrhythmic agents

1993-03-26

1995-02-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424424, 424425, 514821, 6048911, 607120, 607129, A61K 900

Patent

active

053874196

ABSTRACT:
A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl.sub.3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.

REFERENCES:
patent: 4309996 (1982-01-01), Theeuwes
patent: 4344431 (1986-08-01), Yolles
patent: 4615697 (1986-10-01), Robinson
patent: 4627836 (1986-12-01), MacGregor
patent: 4883666 (1989-11-01), Sabel et al.
patent: 5028430 (1991-07-01), Sanders et al.
patent: 5141748 (1992-08-01), Rizzo

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