Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1997-06-03
2000-03-14
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435219, 435325, 530350, 530356, C12Q 137, C07K 14495, C12N 950
Patent
active
060371390
ABSTRACT:
Potential modulators of a procollagen-cleaving enzyme are assessed by determining the ability of the enzyme to cleave procollagen in the presence and absence of a potential modulator in the culture medium of cells induced to secrete a procollagen-cleaving enzyme.
REFERENCES:
patent: 4579821 (1986-04-01), Palmiter et al.
patent: 5807981 (1998-09-01), Brenner
Abe et al. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal. Biochem., (Feb. 1, 1994) 216 (2) 276-84.
Feres-Filho et al. Pre-and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells. J Biol Chem Dec. 22, 1995;270(51):30797-803.
Martin et al. "Osteoblasts: Differentitation and Function", In, Physiology and Pharmacology of Bone vol. 107, eds. Mundy et al., Springer-Verlag, 1993.
Shah et al. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. Journal of Cell Science, (Mar. 1995) 108 (Pt 3) 985-1002.
Centrella et al. Multiple regulatory effects by transforming growth factor-beta on type I collagen levels in osteoblast-enriched cultures from fetal rat bone. Endocrinology, (Dec. 1992) 131 (6) 2863-72,Feb. 1992.
Chan et al. Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro. Biochem. J., (Jul. 1, 1990) 269 (1) 175-81.
Keski-Oja et al. Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. J. Biol. Chem., (Mar. 5 1988) 263 (7) 3.
Hojima et al., "Cadmium Ions Inhibit Procollagen C-Proteinase and Cupric Ions Inhibit Procollagen N-Proteinase," Matrix Biology 14:113-120 (1994).
Lee et al., "Transforming Growth Factor-.beta. Regulation of Bone Morphogenetic Protein-1/Procollagen C-proteinase and Related Proteins in Fibrogenic Cells and Keratinocytes," The Journal of Biological Chemistry 272:19059-19066 (1997).
Bond, Judith S. and Beynon, Robert J., "The Astacin Family of Metalloendopeptidases", Protein Science 4: 1247-1261 (1995).
Colige et al., "cDNA Cloning and Expression of Bovine Procollagen I N-proteinase: A New Member of the Superfamily of zinc-metalloproteinases with Binding Sites for Cells and other Matrix Components", PNAS USA 94:2374-2379 (1997).
Greenspan, D.S., "Mus Musculus Mammalian Tolloid-Like Protein mRNA", Genebank Accession No. U34042. Submitted Aug. 15, 1995.
Johnson, George, "The Chicken with a Duck's Feet: It's All in the Biochemical Signal", The New York Times Science (May 21, 1996.
Kessler et al., "Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase", Science 271: 360-362 (1996).
Nguyen et al., "Characterization of tolloid-related-1: A BMP-1-like Product that is Required During Larval and Pupal Stages of Drosophila Development", Developmental Biology 166: 569-586 (1994).
Takahara et al., "Type I Procollagen COOH-terminal Proteinase Enhancer Protein: Identification, primary Structure, and Chromosomal Localization of the Cognate Human Gene (PCOLCE)", J. Biol. Chem. 269(42): 26280-26285 (1994).
Takahara et al., "Bone Morphogenetic Protein-1 and a Mammalian Tolloid Homolgue (mTld) Are Encoded by Alternatively Spliced Transcripts Which Are Differently Expressed in Some Tissues" J. Biol. Chem. 269 (51): 32572-32578 (1994).
Takahara et al., "Characterization of a Novel Gene Product (Mammalian Tolloid-Like) with High Sequence Similarity to Mammalian Tolloid/Bone Morphogenetic Protein-1", Genomics 34:157-165 (1996).
Takahara et al., "Structural Organization and Genetic Localization of the Human Bone Morphogenetic Protein 1/Mammalian Tolloid Gene", Genomics 29:9-15 (1995).
Wozney et al., "Novel Regulators of Bone Formation: Molecular Clones and Activities", Science 242: 1528-1534 (1988).
ATCC Cell Lines & Hybridomas. Paperback, 632 Pages, Edition No. 08, American Type Culture Collection, ISBN: 0930009541, Editor: Hay, Robert/Chen, T. R. / Macy, Marvin / McClintock, Patrick / Reid, Yvonne / Caputo, Jane. p. 43, 1994.
Alberts et al., Molecular Biology of the Cell, Jan. 1994, Garland Publishing, Inc., New York, NY, p. (s) 111, Jan. 1994.
Greenspan Daniel S.
Lee Seungbok
Kemmerer Elizabeth
Romeo David S.
Wisconsin Alumni Research Foundation
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