System and process for spotting reagents on porous supports

Details System and process for spotting reagents on porous supports System and process for spotting reagents on porous supports

1988-08-15

1989-10-10

Lawrence, Evan

Coating processes

Nonuniform coating

Mask or stencil utilized

118 50, 118406, 118415, 427 2, 427296, B05D 300, B05C 318, B05C 320

Patent

active

048731269

ABSTRACT:
A system having a coating station comprised of a dispensing assembly and a fluid collection head is useful in a method to precisely coat reagents on porous supports for use in diagnostic devices. In the method, a cover having an aperture therethrough and the porous support secured to its underside covering the aperture is positioned in the coating station between the dispensing assembly and the fluid collection head. The reagent is dispensed from a cannula in the dispensing assembly onto the portion of the porous support exposed through the aperture of the cover. A reduced pressure in the fluid collection head pulls fluid through the porous support. The system is automated by providing a guide channel for holding a plurality of covers in correct orientation and a magazine for holding a stack of covers. An indexing arm delivers the bottom-most cover in the stack to the guide channel and urges covers in the channel along its length. The system includes a reciprocating cylinder to bring the dispensing assembly and fluid collection head to the cover for coating and away from the cover after coating. The dispensing assembly may include a template for coating the reagent in a distinct pattern. The system can include a plurality of coating stations to permit coating with a plurality of reagents.

REFERENCES:
patent: 3876449 (1975-04-01), Smith et al.
patent: 4748042 (1988-05-01), Limmecke et al.

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