System and methods for rapid and automated screening of cells

Image analysis – Applications – Biomedical applications

Reexamination Certificate

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C382S133000

Reexamination Certificate

active

07469056

ABSTRACT:
A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

REFERENCES:
patent: 5856665 (1999-01-01), Price et al.
patent: 5932872 (1999-08-01), Price
patent: 6718053 (2004-04-01), Ellis et al.
patent: 6986993 (2006-01-01), Ghosh et al.
patent: WO01/11340 (2001-02-01), None

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