Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-08-28
2007-08-28
McKelvey, Terry (Department: 1655)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
10852644
ABSTRACT:
The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate components. The invention further provides means for optimizing the assay format for the detection of both low and high-affinity antibodies, and provides means for quantitative detection of both antibody and the corresponding antigen present in a sample. In preferred embodiments, the invention can be practiced to detect presence in biological fluid samples of antibodies toBacillus anthracisrelated antigens.
REFERENCES:
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4298685 (1981-11-01), Parikh et al.
patent: 4444879 (1984-04-01), Foster et al.
patent: 4772691 (1988-09-01), Herman
patent: 4778751 (1988-10-01), El Shami et al.
patent: 4945042 (1990-07-01), Geiger et al.
patent: RE34312 (1993-07-01), Geiger et al.
patent: 5236846 (1993-08-01), Senyei et al.
patent: 5236849 (1993-08-01), Ishikawa
patent: 5277589 (1994-01-01), Schmitt et al.
patent: 5312730 (1994-05-01), Piran et al.
patent: 5391272 (1995-02-01), O'Daly et al.
patent: 5534132 (1996-07-01), Vreeke et al.
patent: 5595878 (1997-01-01), Sood et al.
patent: 5705338 (1998-01-01), Piran et al.
patent: 5776702 (1998-07-01), Schmitt et al.
patent: 5895750 (1999-04-01), Mushahwar et al.
patent: 5919633 (1999-07-01), Tausk et al.
patent: 5972199 (1999-10-01), Heller et al.
patent: 5981203 (1999-11-01), Meyerhoff et al.
patent: 5989806 (1999-11-01), Brust
patent: 6030770 (2000-02-01), Brust
patent: 6121006 (2000-09-01), Glover
patent: 6489129 (2002-12-01), Faatz et al.
patent: 6645732 (2003-11-01), Faatz et al.
patent: 6828110 (2004-12-01), Lee et al.
patent: 2002/0082386 (2002-06-01), Mangold et al.
patent: WO97/42221 (1997-11-01), None
Caliceti et al.FarmacoJul. 1993; vol. 48, No. 7, p. 919-32.
Gruber et al.Bioconj. Chem.Jul.-Aug. 1997 vol. 8, No. 4, p. 552-9.
Soltys,BiomaterialsJan. 2000; vol. 21, No. 1, p. 37-48.
Liang et al.,J. Clin. Microbio.(1999) vol. 37, No. 12; p. 3990-3996.
Mathiesen,J. Clin. Microbio.(1998) vol. 36, No. 12, p. 3474-3479.
International Preliminary Examination Report; mailed on Nov. 10, 2003.
International Search Report, completed on Jul. 15, 2002 and mailed on Aug. 22, 2002.
Abrami, et al., Anthrax Triggers Endocytosis of its Receptor Via a Lipid Raft-Mediated Clathrin-Dependent Process, J. Cell Biol. 160(3): 321-328 (2003).
Duesbery, et al., Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor, Science 280:734-737 (1998).
Kaya, et al., Anthrax in Adults and Children: A Review of 132 Cases in Turkey, Eur. J. Clin. Microbiol. Infect. Dis. 21:258-261 (2002).
Leppla, Bacterial Toxins and Virulence Factors in Disease 8:543-572 (1995).
Leppla, Production and Purificaton of Anthrax Toxin, Methods in Enzymology, vol. 165, pp. 103-166 (1998).
Mock and Fouet, Anthrax, Ann. Rev. Microbiol. 55:647-71 (2001).
Morissette, et al., Rapid and Sensitive Sandwich Enzyme-Linked Immunosorbent Assay for Detection ofStaphylococcal enterotoxinB in Cheese, Applied and Environmental Microbiology, Mar. 1991, vol. 57, No. 3, pp. 836-842.
Park and Leppla, Optimized Production and Purification ofBacillus anthracisLethal Factor, Protein Expression and Purification 18(3): 293-302 (2000).
Quinn, et al., Specific, Sensitive, and Quantitative Enzyme-Linked Immunosorbent Assay for Human Immunoglobulin G Antibbodies to Anthrax Toxin Protective Antigen, Emerging Infectious Diseases 8 (10):1103-1110 (20002).
Pellizzari, et al., Anthrax Lethal Factor Cleaves MKK3 in Macrophages and Inhibits the LPS/IFNγ-induced release of NO and TNFα, FEBS Letters 462:199-204 (1999).
Ramirez, et al., Production, Recovery and Immunogenicity of the Protective Antigen from a Recombinant Strain ofBacillus anthracis, J. Ind. Microbiol. Biotech. 28(4): 232-238 (2002).
Sirisanthana, et al., Serological Studies of Patients with Cutaneous and Oral-Oropharyngeal Anthrax from Northern Thailand, Am. J. Trop. Med. Hyg. 39(6):575-581 (1988).
Vitale, et al., Anthrax Lethal Factor Cleaves the N-Terminus of MAPKKs and Induces Tyrosine/Threonine Phosphorylation of MAPKs in Cultured Macrophages, Biochem, Biophys. Res. Comm. 248:706-711 (1998).
Davis Deborah A.
Foley & Hoag LLP
Immunetics, Inc.
McKelvey Terry
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