Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2009-09-23
2011-12-13
Le, Long V. (Department: 3768)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S477000, C600S473000
Reexamination Certificate
active
08078268
ABSTRACT:
System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
REFERENCES:
patent: 5105457 (1992-04-01), Glassman
patent: 5194912 (1993-03-01), Batchelder
patent: 5261410 (1993-11-01), Alfano et al.
patent: 5293872 (1994-03-01), Alfano
patent: 5377004 (1994-12-01), Owen
patent: 5442430 (1995-08-01), Ishii
patent: 5442438 (1995-08-01), Batchelder
patent: 5452723 (1995-09-01), Wu
patent: 5528393 (1996-06-01), Sharp
patent: 5539517 (1996-07-01), Cabib
patent: 5596992 (1997-01-01), Haaland
patent: 5623342 (1997-04-01), Baldwin
patent: 5689333 (1997-11-01), Batchelder
patent: 5710626 (1998-01-01), O'Rourke
patent: 5733739 (1998-03-01), Zakim et al.
patent: 5769081 (1998-06-01), Alfano
patent: 5799656 (1998-09-01), Alfano
patent: 5862273 (1999-01-01), Pelletier
patent: 5891619 (1999-04-01), Zakim
patent: 5901261 (1999-05-01), Wach
patent: 5911017 (1999-06-01), Wach
patent: 6002476 (1999-12-01), Treado
patent: 6151522 (2000-11-01), Alfano
patent: 6167287 (2000-12-01), Chozui
patent: 6167297 (2000-12-01), Benaron
patent: 6205354 (2001-03-01), Gellermann
patent: 6485413 (2002-11-01), Boppart
patent: 6571118 (2003-05-01), Utzinger
patent: 6640132 (2003-10-01), Freeman
patent: 6665556 (2003-12-01), Alfano
patent: 6741884 (2004-05-01), Freeman
patent: 6748259 (2004-06-01), Benaron
patent: 6937885 (2005-08-01), Lewis
patent: 7039452 (2006-05-01), McClane
patent: 7515952 (2009-04-01), Balas
patent: 2001/0052979 (2001-12-01), Treado
patent: 2001/0055462 (2001-12-01), Seibel
patent: 2002/0007123 (2002-01-01), Balas
patent: 2002/0113210 (2002-08-01), Treado
patent: 2003/0004419 (2003-01-01), Treado
patent: 2003/0114762 (2003-06-01), Balas
patent: 2003/0130579 (2003-07-01), McClane
patent: 2004/0038320 (2004-02-01), Banerjee
patent: 2004/0068193 (2004-04-01), Barnes
patent: 2004/0152992 (2004-08-01), Zeng
patent: 2005/0240107 (2005-10-01), Alfano
patent: 2006/0013454 (2006-01-01), Flewelling et al.
patent: 2006/0155195 (2006-07-01), Maier
patent: 2006/0250613 (2006-11-01), Demuth et al.
patent: 2006/0253261 (2006-11-01), Maier
patent: 2006/0269972 (2006-11-01), Smith
patent: 2006/0281068 (2006-12-01), Maier
patent: 2007/0093708 (2007-04-01), Benaron
patent: PCT/US06/06663 (2006-08-01), None
Storrie-Lombardi et al, “Hollow Cathode Ion Lasers for Deep Ultraviolet Raman Spectroscopy and Fluorescence Imaging.” Review of Scientific Instruments, vol. 72, No. 12. Dec. 1, 2001.
Uzunmajakava et al, “Combined Raman and Continuous-Wave Excited Two-Photon Fluorescence Cell Imaging,” Optics Letters Opt. Soc. America USA, vol. 28, No. 21. Nov. 1, 2003.
Morris et al, “Imaging Spectrometers for Fluorescence and Raman Microscopy: Acousto-Optic and Liquid Crystal Tunable Filters,” Applied Spectrscopy, vol. 48, No. 7, Jul. 1994.
Morris et al, “Fluorescence and Raman Chemical Imaging of Thermoplastic Olefin (TPO) Adhesion Promotion,” Langumuir 1998, vol. 14, No. 9.
European Search Report, PCT/US2005/023705, Nov. 6, 2009.
Sajid et al, “Fourier Transform Vibrational Spectroscopic Analysis of Human Cerebral Tissue,” Journal of Raman Spectroscopy (1997) pp. 165-169, vol. 28.
Boppart et al, “Optical Coherence Tomography for Neurological Imaging of Human Intracortical melanoma.” Neurosurgery (1998) pp. 834-841, vol. 43.
Haka et al, “Identifying Microcalicifications in Benign and Malignant Breast Lesions by Probing Differences in Their Chemical Composition Using Raman Spectroscopy,” Cancer Research (2002) pp. 5375-5380, vol. 62.
Hanlon et al, “Prospects for In Vivo Raman Spectroscopy,” Phy. Med. Biol. (2000) pp. R1-R59, vol. 45.
Lakshmi et al, “Tisue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiation Research (2002) pp. 175-182, vol. 157.
Liu et al, “Near-IR Fourier Transform Raman Spectroscopy of Normal and Atherosclerotic Human Aorta,” Lasers in Life Science (1992) pp. 257-264, vol. 4.
Miura et al, “Binding Mode of Congo Red to Alzheimer's Amyloid B-peptide Studied by UV Raman Spectroscopy,” Journal of Raman Spectroscopy (2002) pp. 530-535, vol. 33.
Mizuno et al, “Near Infrared FT-Raman Spectra of the Rat Brian Tissues,” Neuorscience Letters (1992) pp. 47-52. vol. 141.
Mizuno et al, “Near infrared Fourier Transform Raman Spectroscopic Study Human Brain—Tissues and Tumors,” Journal of Raman Spectroscopy (1994) pp. 25-29, vol. 25.
Naumann, D, “FT-Infrared and FT-Raman Spectroscopy in Biomedical Research,” Applied Spectroscopy Reviews (2001) pp. 239-289 vol. 36.
Petrich, W., “Mid-Infrared and Raman Spectroscopy for Medical Diagnostics,” Applied Spectroscopy Reviews (2001) pp. 181-237, vol. 36.
Chandler et al, “Intraoperative Use of Real Time Ultrasonography in Neurosurgery,” J Neuorsurg (1982) pp. 157-163, vol. 57.
Poon et al, “Laser-induced Fluorescence : Experimental Intraoperative Delineation of tumor Resection Margins,” J. Neurosurg (1992) pp. 679-686 vol. 76.
Hansen et al, “Indocyanine Green (ICG) Staining an dDemarcation of Tumor Margins in a Rat Glloma Model,” Surgical Neurol. (1993) pp. 451-456, vol. 40.
Haglund et al, “Enhanced Optical Imaging of Rat Gilomas and Tumor Margins,” Neurosurgery (1994) pp. 930-941 vol. 35 No. 5.
Yuan et al, “Isolation of Cancer Stem Cells from Audit Glioblastoma Multiforme,” Oncogene (2004) pp. 9392-9400, vol. 23.
Ahmad, K. “Small Subsets of Cells Initiate Brain Tumors,” Lancet Oncology (2005), pp. 9, vol. 6.
Dirks, P.B. “Brain Tumor Stem Cells,” Biology of Blood Marrow Transplantation, (2005) pp. 12-13, vol. 11.
Bakker Schut et al, “Real Time Tissue Characterization on the Basis of In Vivo Raman Spectra,” Journal of Raman Spectroscopy, 2002, pp. 580-585 vol. 33.
Dong et al, Metal Binding and Oxidation of Amyloid-B Within Isolated Senile Plaque Cores: Raman Microscopic Evidence, Biochemicstry (2003), pp. 2768-2773, vol. 42.
Frank et al, “Characterization of Human Breast Biopsy Specimens with Near IR Raman Spectroscopy,” Analytical Chemistry (1994) pp. 319-326, vol. 66.
Talbot et al, “Appliction of Fluorescence Lifetime and Hyperspectral Imaging to Tissue Autofluorescence: Arthritis,” European Conference on Biomedical Optics (ECBO), Conference Paper, Jun. 12, 2005.
Goodship, A.E. et al., Kerr-Gated Picosecond Spectroscopy and Raman Photon Migration of Equine Bone Tissue, Central Laser Facility Annual Report, 2003/2004, pp. 129-130.
Treado, Patrick J., Chemical Imaging Reveals More than Microscope, Laser Focus World, 10438092, Oct. 1995, vol. 31, Issue 10, pp. 76-81.
Cederquist, Sally C., Laser-Raman Provides a View of Microfossils, Laser Focus World, 07402511, Jun. 2001, vol. 37, Issue 6, pp. 26-28.
PCT/US2006/06663, Written Opinion, mailed on Feb. 13, 2008.
CT/US2006/06663, Search Report, mailed on Feb. 13, 2008.
CT/US2006/06663, International Preliminary Report on Patentability.
Cohen Jeffrey
Maier John S.
Nelson Matthew
Stewart Shona
Treado Patrick J
Bor Helene
ChemImage Corporation
Le Long V.
LandOfFree
System and method of chemical imaging using pulsed laser... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System and method of chemical imaging using pulsed laser..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method of chemical imaging using pulsed laser... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4316248