System and method for transdermal drug delivery

Details System and method for transdermal drug delivery System and method for transdermal drug delivery

1989-05-22

1991-07-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424447, 424448, 424449, 424486, A61K 914, A61K 1302

Patent

active

050284355

ABSTRACT:
Transdermal drug delivery systems comprise a backing or enclosure having a matrix layer which incorporates a drug and a percutaneous enhancer for the drug. The percutaneous enhancer and/or drug will be contained within polymeric particles dispersed through the matrix layer, where the polymeric particles define pore networks which are sized to release the enhancer and/or drug into the matrix layer at rate(s) selected to provide for a desired rate of drug penetration. By isolating the enhancer within the polymeric particles, adverse interactions between the enhancer and the matrix layer and/or the drug can be minimized. Moreover, the release rate of the enhancer into the matrix layer can be carefully controlled, which in turn controls the penetration rate of the drug into the treated host.

REFERENCES:
patent: 3797494 (1974-03-01), Zaffaroni
patent: 4687481 (1987-08-01), Nuwayser
patent: 4783335 (1988-11-01), Lipshitz

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