Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-10-17
2006-10-17
Vo, Tim (Department: 2168)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S027000
Reexamination Certificate
active
07124032
ABSTRACT:
A system and method for reconstructing pathways in large genetic networks from genetic perturbations comprises an analysis method and system that applies a recursive algorithm for determining the path between every gene pair in an arbitrarily large genetic network from large-scale gene perturbation data and reconstructs all direct and indirect regulatory gene interactions in the network. Graph theory mathematics is applied to genetic network reconstruction in the following manner: Genetic perturbation data is used to identify all genes accessible from a perturbed gene to generate an accessibility list for the gene. Graph theory mathematics is applied to the accessibility list and its graph to determine a condensation of the graph as defined by the condensation's accessibility list. Graph theory mathematics is applied to the accessibility list, such as through a recursive algorithm performed on a desktop computer, to obtain an adjacency list for the gene that characterizes a genetic network.
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Michael B. Eisen et al, 1998 Cluster Analysis and Display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America, vol. 95:14863-1488.
Andreas Wagner. The Yeast Protein Interaction Network Evolves Rapidy and Contains Few Redundant Duplicate Genes. Molecular Biology and Evolution, vol. 18(7): 1283-1292, (2001).
Saeed Tavazoie et al, 1999 Systematic Determination of Genetic Network Architecture. Nature Genetics, vol. 22: 281-285.
Baniak Pine & Gannon
Ly Cheyne D.
Science & Technology Corporation @ UNM
Vo Tim
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