System and method for on-line coupling of liquid capillary separ

Details System and method for on-line coupling of liquid capillary separ System and method for on-line coupling of liquid capillary separ

1998-05-29

2000-10-31

Nguyen, Kiet T.

Radiant energy

Ionic separation or analysis

With sample supply means

H01J 4904

Patent

active

061406392

ABSTRACT:
The invention relates to a system and method for on-line coupling of liquid capillary separation with matrix-assisted laser desorption ionization mass spectrometric analysis. In this system and method, analyte from liquid capillary separation is mixed with matrix molecules for matrix-assisted laser desorption ionization. Continuous flow of the analyte/matrix combined with vacuum conditions allows evaporation and crystallization of homogeneous samples on a solid sample surface. Dual use of laser irradiation to desorb/ionize and remove excess sample facilitates on-line use and automation.

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