System and method for in vitro analysis of therapeutic agents

Details System and method for in vitro analysis of therapeutic agents System and method for in vitro analysis of therapeutic agents

2006-04-25

2006-04-25

Toatley, Jr., Gregory J. (Department: 2877)

Optics: measuring and testing

Sample, specimen, or standard holder or support

Fluid containers

C356S319000

Reexamination Certificate

active

07034933

ABSTRACT:
A system and method for in vitro analysis of therapeutic agents comprising a reservoir adapted to hold a therapeutic agent, a first flow cell having a first cell chamber adapted to receive at least a first sample of the therapeutic agent, a second flow cell having a second cell chamber adapted to receive at least a second sample of the therapeutic agent, the first flow cell having a first path length (be′) and the second flow cell having a second path length (be″), the first path length being substantially equal to a sensitivity factor (f)×be″, a membrane chamber having a biological cell membrane therein adapted to receive at least a third sample of the therapeutic agent, the membrane chamber being further adapted to detect the membrane potential of the biological cell membrane; and spectroscopic detection means for detecting the spectral characteristics of the first and second therapeutic agent samples.

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