System and method for improving sample concentration in capillar

Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge

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204299R, G01N 2726, B01D 5702

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active

051164710

ABSTRACT:
The method for improving sample concentration in capillary electrophoresis by extracting the sample buffer from the capillary column using the electro-osmotic flow while the sample components are stacked into the support buffer utilizes a system for this technique. The system has a separation column 11, sample introduction means 16 for injecting the sample solution, an injection detector means 20 for detecting the volume of injected sample solution, a separation detector means 21 for detecting the sample components, power supply means 17 for applying a high voltage along the separation column 11 for reversing the direction of the electro-osmotic flow thereby causing extraction of the sample buffer from the separation column and afterward providing the separation sample into its components.

REFERENCES:
Ruedi Aebersold & Hamish D. Morrison "Analysis of dilute peptide samples by capillary zone electrophoresis" Journal of Chromatography 516 (1990) 79-88.
Henk H. Lauer et al. "Analytical Aspects of an Automated Capillary Electrophoresis System" LC-GC vol. 6, No. 1 (1990) 34-46.
F. E. B. Mikkers, F. M. Everaerts, & Th. P. E. M. Verheggen "High-Performance Zone Electrophoresis" Journal of Chromatography 169 (1979) 11-20.
Dean S. Burgi & Ring-Ling Chien "Optimization in Sample Stacking for High-Performance Capillary Electrophoresis" Analytical Chemistry, vol. 63, No. 18 (1991) 2042-2047.
Moring, Stephen E., "Analytical Aspects of an Automated Capillary Electrophoresis System," LC-GC, vol. 8, No. 1 (1990) 34-46.
Jorgenson, James W. et al. "Capillary Zone Electrophoresis", Science, vol. 222, (1983), pp. 266-272.
Nielen, M. W. F., "Impact of Experimental Parameters on the Resolution of Positional Isomers of Aminobenzoic Acid in Capillary Zone Electrophoresis," Journal of Chromatography, 542 (1991) 173-183.

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