System and method for identifying optimized blood signal in...

Details System and method for identifying optimized blood signal in... System and method for identifying optimized blood signal in...

2007-06-19

2007-06-19

Casler, Brian L. (Department: 3768)

Image analysis

Applications

Biomedical applications

C600S420000

Reexamination Certificate

active

10811887

ABSTRACT:
In a sequence of medical image data showing tumors and blood vessels, a plasma signal is optimized to avoid flow artifacts by receiving a user input of a blood region and using the user input to seed an automated search. Each voxel is scored by time point of maximum intake, slope at maximum intake, peak value and conformance to a gamma variate curve, and the voxels with the highest scores are included in the ideal plasma region of interest. Uptake curves for both tumors and plasma are determined and used to estimate a volume transfer constant.

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Mark Rijpkema, et al. “Method for Quantitative Mapping of Dynamic MRI Contrast Agent Uptake In Human Tumors”, Journal of Magnetic Resonance Imaging 14:457-463, 2001, pp. 457-463.

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