Data processing: structural design – modeling – simulation – and em – Modeling by mathematical expression
Reexamination Certificate
2011-01-25
2011-01-25
Smith, Carolyn L. (Department: 1631)
Data processing: structural design, modeling, simulation, and em
Modeling by mathematical expression
C702S142000, C702S149000, C702S150000, C702S155000, C702S179000, C703S011000
Reexamination Certificate
active
07877241
ABSTRACT:
Psychopharmacological properties of new therapeutic drugs and highly heritable behavior patterns of test subjects are identified based on analysis of monitored exploratory movement to identify behavioral signatures. A test subject in a pen is allowed to explore for a period of time, after injecting it with a candidate drug or control vehicle. The test subject's movement is monitored and its locations stored. The locations are analyzed to separate them into behavioral patterns that are defined based on combinations of behavioral feature. Relative frequencies of performing each behavioral pattern are determined. In each pattern, differences between the relative frequencies in the candidate drug and control groups are tested, and only patterns in which this difference is highly significant are retained. The number of behavioral patterns further is reduced based on the relative frequencies and the correlation of behavioral patterns to one another, with the cells left over corresponding to a set of endpoints that identify a behavioral signature of the effect of the drug.
REFERENCES:
patent: 7269516 (2007-09-01), Brunner et al.
patent: 2003/0100998 (2003-05-01), Brunner et al.
Arnold, J.C., The role of endocannabinoid transmission in cocaine addiction.Pharmacol Biochem Behav, 2005. 81(2): p. 396-406.
Baron, S.P. and J.H. Woods, Competitive and uncompetitive N-methyl-D-aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine.Psychopharmacology(Berl), 1995. 118(1): p. 42-51.
Beardsley, P.M., M.D. Aceto, C.D. Cook, E.R. Bowman, J.L. Newman, and L.S. Harris, Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys.Exp Clin Psychonpharmacol, 2004. 12(3): p. 163-72.
Beardsley, P.M. and B.F. Thomas, Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders.Behav Pharmacol, 2005. 16(5-6): p. 275-96.
Benjamini, Y., Drai, D., Elmer, G., Kafkafi, N. & Golani, I. (2001) Controlling the false discovery rate in behavior genetics research.Behav Brain Res125(1-2), 279-284.
Benjamini Y. & Yekutieli D. (2005) False discovery rate-adjusted multiple confidence intervals for selected parameters.J Amer Stat Assoc100, 71-93.
Brebner, K., A.R. Childress, and D.C. Roberts, A potential role for GABA(B) agonists in the treatment of psychostimulant addiction.Alcohol Alcohol, 2002. 37(5): p. 478-84.
Broadhurst, P. L. (1975). The Maudsley reactive and nonreactive strains of rats: A survey.Behav. Genet5, 299-319.
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L. & Cleveland, D.W. (1997) ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.Neuron18, 327-338.
Bruijn, L. I., Miller, T. M. & Cleveland, D. W. (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS.Annu Rev Neurosci27, 723-749.
Chesler, E. J., Wilson, S. G., Lariviere, W. R., Rodriguez-Zas, S. L. & Mogil, J. S. (2002) Influences of laboratory environment on behavior.Nature Neurosci5, 1101-1102.
Chiu, A.Y., Zhai, P., Dal Canto, M.C., Peters, T.M., Kwon, Y.W., Prattis, S.M. & Gurney, M.E., (1995) Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis.Mol Cell Neurosci6, 349-362.
Collins, G.T., J.M. Witkin, A.H. Newman, K.A. Svensson, P. Grundt, J. Cao, and J.H. Woods, Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.J Pharmacol Exp Ther, 2005. 314(1): p. 310-19.
Compton, W.M. and N.D. Volkow, Major increases in opioid analgesic abuse in the United States: Concerns and strategies.Drug Alcohol Depend, 2006. 81: p. 103-7.
Crabbe, J. C., Wahlsten, D. & Dudek, B. C. (1999) Genetics of mouse behavior: Interactions with laboratory environment.Science284 (5420), 1670-1672.
Dackis, C.A., K.M. Kampman, K.G. Lynch, H.M. Pettinati, and C.P. O'Brien, A double-blind, placebo-controlled trial of modafinil for cocaine dependence.Neuropsychopharmacology, 2005. 30(1): p. 205-11.
Desai, R.I., T.A. Kopajtic, M. Koffarnus, A.H. Newman, and J.L. Katz, Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.J Neurosci, 2005. 25(8): p. 1889-93.
Drai, D., Benjamini, Y. & Golani, I. (2000) Statistical discrimination of natural modes of motion in rat exploratory behavior.J Neurosci Methods96(2), 119-31.
Drai, D., Kafkafi, N., Benjamini, Y., Elmer, G. I. & Golani, I. (2001) Rats and mice share common ethologically relevant parameters of exploratory behavior.Behav Brain Res125(1-2), 133-140.
Drai, D. & Golani, I. (2001) SEE: a tool for the visualization and analysis of rodent exploratory behavior.Neurosci Biobehav Rev, 25 (5), 409-426.
Derave, W., Van Den Bosch, L., Lemmens, G., Eijnde, B.O., Robberecht, W. & Hespel, P. (2003) Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment.Neurobiol Dis13 (3), 264-72.
Elmer, G.I., D.A. Gorelick, S.R. Goldberg, and R.B. Rothman, Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype.Pharmacol Biochem Behav, 1996. 53(3): p. 623-28.
Elmer, G.I., J.O. Pieper, S.S. Negus, and J.H. Woods, Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests.Pain, 1998. 75(1): p. 129-40.
Elmer, G.I., J.O. Pieper, J. Levy, M. Rubinstein, M.J. Low, D.K. Grandy, and R.A. Wise, Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice.Psychopharmacology(Berl), 2005. 182(1): p. 33-44.
Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M., Castellano-Sanchez, A., Khan, J., Polak, M. A. & Glass, J. D. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man.Exp Neurol185, 232-240.
Grammer, M., Kuchay, S,. Chishti, A. & Baudry, M. (2005) Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice.Neurobiol Learn Mem84(3), 222-227.
Gurney, M.E., Pu, H., Chiu, A.Y., Dal Canto, M.C., Polchow, C.Y., Alexander, D.D., Caliendo, J., Hentati, A., Kwon, Y.W., Deng, H.X. et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.Science264(5166), 1772-1775.
Haney, M., C.L. Hart, and R.W. Foltin, Effects of Baclofen on Cocaine Self-Administration: Opioid- and Nonopioid-Dependent Volunteers.Neuropsychopharmacology, 2006. 31, 1814-21.
Heidbreder, C.A. and J.J. Hagan, Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving.Curr Opin Pharmacol, 2005. 5(1): p. 107-18.
Hen, I., Sakov, A., Kafkafi, N., Golani, I. & Benjamini, Y. (2004) The dynamics of spatial behavior: how can robust smoothing techniques help?J Neurosci Methods133(1-2), 161-172.
Horev, G., Benjamini, Y., Sakov, A. & Golani, I. (in press) Estimating wall guidance and attraction in mouse free locomotor behavior.Genes Brain Behav(2007) 6: 30-41.
Howland, D.S., Liu, J., She, Y., Goad, B., Maragakis, N.J., Kim, B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G., DeGennaro, L.J., Cleveland, D.W. & Roth-stein, J.D., (2002). Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).Proc Natl Acad Sci USA99, 1604-1609.
Jayaram, N., C. Mayo, H. Guard, and G.I. Elmer, Discriminating the effects of typical from atypical antipsychotics in the C57BL/6J mouse.Soc for Neurosci Abstracts, 2003. Prog No. 385.21.
Kafkafi N, Mayo C, Drai D, Golani I, Elmer G. (2001) Natural segmentation of the locomotor behavior of drug-induced rats in a photobeam cage.J. Neurosci Methods109(2), 111-21.
Kafkafi, N. (2003) Extending SEE for large-scale phenotyping of mouse open-field behavior.Behav Res Methods Instrum Comput35(2), 294-301.
Kafkafi, N., Lipkind, D., Benjamin
Elmer Gregory
Kafkafi Neri
Gibb I.P. Law Firm LLC
Smith Carolyn L.
University of Maryland Baltimore
LandOfFree
System and method for identifying behavioral signatures does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System and method for identifying behavioral signatures, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method for identifying behavioral signatures will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2709286