System and method for fragmentation mapping

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2041828, 364497, 364499, 935 75, 935 76, G05F 1542, G06G 758

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active

047713844

ABSTRACT:
A system and method for the construction of one-dimensional maps from fragmentation data is disclosed. Particularly useful for construction of restriction maps of DNA, the system and method completely permutes sites, single digest fragments, and any available multiple digest fragments, and displays maps in rank-order according to a quality factor. Display of constructed maps includes information about relative ordering of all fragments, sites, and particularly about closely-spaced sites and fragments.

REFERENCES:
patent: 4412288 (1983-10-01), Herman
patent: 4518690 (1985-05-01), Guntaka
patent: 4675283 (1987-06-01), Roninson
Pearson, William R., Automatic Construction of Restriction Site Maps, Nucleic Acids Research, vol. 10 No. 1 1982.
Nolan, Garry P. et al., Plasmid Mapping Computer Program, Nucleic Acids Research, vol. 12 No. 1 1984.
Durand and Gregegere, An Efficient Program to Construct Restriction Maps from Experimental Data with Realistic Error Levels, Nucleic Acids Research, vol. 12 No. 1 1984.
Wulkan and Lott, Computer-Aided Construction of Nucleic Acid Restriction Maps Using Defined Vectors, Cabios, vol. 1, No. 4 1985.
Fitch, Smith & Ralph, Mapping the Order of DNA Restriction Fragments, Gene, vol. 22 1983.

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