System and method for forming synthetic protein crystals to dete

Details System and method for forming synthetic protein crystals to dete System and method for forming synthetic protein crystals to dete

1996-04-08

1997-01-28

Phasge, Arun S.

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

205688, 378 73, 378 78, 4351731, 4351732, 4351733, C10M17100, C10M16904

Patent

active

055974570

ABSTRACT:
A method for forming synthetic crystals of proteins in a carrier fluid by use of the dipole moments of protein macromolecules that self-align in the Helmholtz layer adjacent to an electrode. The voltage gradients of such layers easily exceed 10.sup.6 V/m. The synthetic protein crystals are subjected to x-ray crystallography to determine the conformational structure of the protein involved.

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A. M. Edwards, S. A. Darst, S. A. Hemming, Y. Li, and R. D. Kornberg, "Epitaxial growth of protein crystals on lipid layers", Structural Biology, vol. 1, No. 3, pp. 195-197, Mar. 1994.
M. F. Toney, J. N. Howard, J. Richer, G. L. Borges, J. G. Gordon, O. R. Melroy, D. G. Wiesler, D. Yee, and L. B. Sorensen, "Voltage-dependent ordering of water molecules at a electrode-electrolyte interface", Nature, vol. 368, pp. 444-446, Mar. 1994.
C. Okazaki and K. Takeda, "Electrically-Induced Memory Effect in Bacteriorhodopsin", Jpn. J. Appl. Phys. vol. 34, Part 1, No. 4A, pp. 1963-1967, (1995).

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