System and method for forming a cardiac muscle construct

Details System and method for forming a cardiac muscle construct System and method for forming a cardiac muscle construct

2008-03-04

2008-03-04

Saucier, Sandra E. (Department: 1657)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Reexamination Certificate

active

07338798

ABSTRACT:
A system and method for forming a cardiac muscle construct are provided, the system including a substrate and cardiac cells provided on the substrate in the absence of a scaffold. The cardiac cells are cultured in vitro under conditions to allow the cells to become confluent and detach from the substrate to form a three-dimensional cardiac muscle construct.

REFERENCES:
patent: 4605623 (1986-08-01), Malette et al.
patent: 4642292 (1987-02-01), Reid et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4940853 (1990-07-01), Vandenburgh
patent: 5153136 (1992-10-01), Vandenburgh
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5618718 (1997-04-01), Auger et al.
patent: 5756350 (1998-05-01), Lee et al.
patent: 6114164 (2000-09-01), Dennis et al.
patent: 6207451 (2001-03-01), Dennis et al.
patent: 6303286 (2001-10-01), Dennis et al.
patent: 6448076 (2002-09-01), Dennis et al.
patent: 6777234 (2004-08-01), Dennis et al.
patent: 2001/0049138 (2001-12-01), Dennis et al.
Zimmermann et al , Three-DImensional Engineered Heart Tissue from Neonatal Rat Cardiac Myocytes, Biotechnology and Bioengineering, vol. 68, No. 1, p. 106-114, 2000.
Shimizu, Tatsuya, Cardiac Tissue Engineering-Myocardial Tissue Construction using Biomaterials, 2000, Igaku no Ayumi, vol. 195, p. 203-204.
Shimizu et al, Cell Sheet engineering for myocardial tissue reconstruction,2003,Biomaterials, vol. 24, p. 2309-2316.
L.W. Stevenson et al., “The Impending Crisis Awaiting Cardiac Transplantation”, Circulation, vol. 89, No. 1, Jan. 1994, pp. 450-457.
R.E. Akins et al., “Cardiac Organogenesis in vitro: Reestablishment of Three-Dimensional Tissue Architecture by Dissociated Neonatal Rat Ventricular Cells”, Tissue Engineering, vol. 5, No. 2, 1999, pp. 103-118.
M. Muthuchamy et al., “Developmental Analysis of Tropomyosin Gene Expression in Embryonic Stem Cells and Mouse Embryos”, Molecular and Cellular Biology, Jun. 1993, vol. 13, No. 6, pp. 3311-3323.
I. Harary and B. Farley, “In Vitro Studies On Single Beating Rat Heart Cells”, Experimental Cell Research 29, 1963, pp. 451-465.
T. Eschenhagen et al., “Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system”, The FASEB Journal, vol. 11, Jul. 1997, pp. 683-694.
L. Saggin et al., “Troponin T Switching in the Developing Rat Heart”, The Journal of Biological Chemistry, vol. 263, No. 34, Dec. 15, 1988, pp. 18488-18492.
P. Anderson and A. Oakeley, “Immunological Identification of Five Troponin T Isoforms Reveals an Elaborate Maturational Troponin T Profile in Rabbit Myocardium”, Circulation Research, vol. 65, No. 4, Oct. 1989, pp. 1087-1093.
L. Gao et al., “Differential Expression of TnI and TnT Isoforms in Rabbit Heart during the Perinatal Period and during Cardiovascular Stress”, J. Mol. Cell. Cardiol. 27, 1995, pp. 541-550.
W. Zimmermann et al., “Cardiac Grafting of Engineered Heart Tissue in Syngenic Rats”, Circulation Research, Sep. 24, 2002, pp. I-151-I-157.
W. Zimmermann et al., “Tissue Engineering of a Differentiated Cardiac Muscle Construct”, Circulation Research, Feb. 8, 2002, pp. 223-230.
T. Kofidis et al., “A novel bioartificial myocardial tissue and its prospective use in cardiac surgery”, European Journal of Cardio-thoracic Surgery, 22, 2002, pp. 238-243.
A. Kadner et al., “Human Umbilical Cord Cells: A New Cell Source for Cardiovascular Tissue Engineering”, Annals of Thoracic Surgery 74, 2002, pp. S1422-S1428.
R. Dennis and P. Kosnik, “Excitability and Isometric Contractile Properties of Mammalian Skeletal Muscle Constructs Engineered In Vitro”, In Vitro Cell. Dev. Biol., May 2000, pp. 327-335.
R. Dennis et al., “Excitability And Contractility Of Skeletal Muscle Engineered From Primary Cultures And Cell Lines”, Am. J. Physiol Cell Physiol, 2001, C288-C295.
R. Carrier et al., “Cardiac Tissue Engineering: Cell Seeding, Cultivation Parameters, and Tissue Construct Characterization”, Biotechnology and Bioengineering, vol. 64, No. 5, Sep. 5, 1999, pp. 580-589.
R. Akins, “Can Tissue Engineering Mend Broken Hearts?”, Circulation Research, Feb. 8, 2002, pp. 120-122.
P. Akhyari et al., “Mechanical Stretch Regimen Enhances the Formation of Bioengineered Autologous Cardiac Muscle Grafts”, Circulation, Sep. 24, 2002, pp. I-137-I-142.
Vandenburgh et al., Skeletal Muscle Growth is Stimulated by Intermittent Stretch-Relaxation in Tissue Culture, American Psych. Society, 1989, pp. C674-682.
Vandenburgh, A Computerized Mechanical Cell Stimulator for Tissue Culture Effects on Skeletal Muscle Organogenesis, In Vitro Cellular & Developmental Biology, vol. 24, No. 7, Jul. 1988, pp. 609-619.
Vandenburgh et al., Longitudinal Growth of Skeletal Myotubes in Vitro in a New Horizontal Mechanical Cell Stimulator, In Vitro Cell Dev. Bio., vol. 25, No. 7, Jul. 1989, pp. 607-616.
Vandenburgh et al., Computer-Aided Mechanogenesis of Skeletal Muscle Organs from Single Cells In Vitro, The FASEB Journal, vol. 5, Oct. 1991, pp. 2860-2867.
Vandenburgh et al., Tissue-Engineered Skeletal Muscle Organoids for Reversible Gene Therapy, Humane Gene Therapy, Nov. 1996, pp. 2195-2200.
Shansky et al., Letter to the Editor: A Simplified Method for Tissue Engineering Skeletal Muscle Organoids In Vitro, In Vitro Cell. Dev. Biol., Oct. 1997, pp. 659-661.
T. Shimizu et al., “Two-Dimensional Manipulation of Cardiac Myocyte Sheets Utilizing Temperature-Responsive Culture Dishes Augments the Pulsatile Amplitude”, Tissue Engineering, vol. 7, No. 2, 2001, pp. 141-151.
T. Shimizu et al., “Electrically communicating three-dimensional cardiac tissue mimic fabricated by layered cultured cardiomyocyte sheets”, Journal of Biomedical Materials Research 60, pp. 110-117, 2002.
T. Sakai et al., “The Fate Of A Tissue-Engineered Cardiac Graft In The Right Ventricular Outflow Tract Of The Rat”, The Journal of Thoracic and Cardiovascular Surgery, vol. 121, No. 5, May 2001, pp. 932-942.
M. Papadaki et al., “Tissue Engineered Of Functional Cardiac Muscle: Molecular, Structural, and Electrophysiological Studies”, Am. J. Physiol Heart Circ. Physiol 280, 2001, pp. H168-H178.
T. McDevitt et al., “In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces”, Journal of Biomedicial Materials Research 60, 2002, pp. 472-479.
W. Liu et al., “Developmental changes of Ca2-handling in mouse ventricular cells from early embryo to adulthood”, Life Sciences 71, 2002, pp. 1279-1292.
J. Leor et al., “Bioengineered Cardiac Grafts, A New Approach To Repair The Infracted Myocardium?”, Circulation, Nov. 7, 2000, pp. III-56-III-61.
P. Kosnik et al., “Functional Development of Engineered Skeletal Muscle From Adult And Neonatal Rats”, Tissue Engineering, vol. 7, Nov. 5, 2001, pp. 573-584.
T. Kofidis et al., “In vitro engineering of heart muscle: Artificial Myocardial tissue”, The Journal of Thoracic and Cardiovascular Surgery, vol. 124, No. 1, pp. 63-69, 2002.

Affiliated with

Also associated with

Rating

System and method for forming a cardiac muscle construct does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with System and method for forming a cardiac muscle construct, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method for forming a cardiac muscle construct will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2784819