Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2007-11-20
2007-11-20
Schaetzle, Kennedy (Department: 3766)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S513000
Reexamination Certificate
active
11043804
ABSTRACT:
Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.
REFERENCES:
patent: 4731051 (1988-03-01), Fischell
patent: 4947845 (1990-08-01), Davis
patent: 5113869 (1992-05-01), Nappholz et al.
patent: 5135004 (1992-08-01), Adams et al.
patent: 5199428 (1993-04-01), Obel et al.
patent: 5203326 (1993-04-01), Collins
patent: 5313953 (1994-05-01), Yomtov et al.
patent: 5365426 (1994-11-01), Siegel et al.
patent: 5520191 (1996-05-01), Karlsson et al.
patent: 5741211 (1998-04-01), Renirie et al.
patent: 5891047 (1999-04-01), Lander et al.
patent: 5960797 (1999-10-01), Kramer et al.
patent: 6016443 (2000-01-01), Ekwall et al.
patent: 6021350 (2000-02-01), Mathson
patent: 6038469 (2000-03-01), Karlsson et al.
patent: 6108577 (2000-08-01), Benser
patent: 6112116 (2000-08-01), Fischell et al.
patent: 6115628 (2000-09-01), Stadler et al.
patent: 6128526 (2000-10-01), Stadler et al.
patent: 6233486 (2001-05-01), Ekwall et al.
patent: 6256538 (2001-07-01), Ekwall
patent: 6264606 (2001-07-01), Ekwall et al.
patent: 6272379 (2001-08-01), Fischell et al.
patent: 6377852 (2002-04-01), Bornzin et al.
patent: 6381493 (2002-04-01), Stadler et al.
patent: 6501983 (2002-12-01), Natarajan et al.
patent: 6572542 (2003-06-01), Houben et al.
patent: 7016720 (2006-03-01), Kroll
patent: 7029443 (2006-04-01), Kroll
patent: 7103412 (2006-09-01), Kroll
patent: 2002/0143372 (2002-10-01), Snell et al.
patent: 2004/0077962 (2004-04-01), Kroll
patent: 2004/0138716 (2004-07-01), Kon et al.
patent: 0 939 602 (2004-09-01), None
patent: WO97/15227 (1997-01-01), None
Eckert, Bodil, et al. “Hypoglycaemia Leads to an Increased QT Interval in Normal Men,”Clinical Physiology, May 1998; vol. 18, No. 6, pp. 570-575.
Heller, Simon R., “Abnormalities of the Electrocardiogram During Hypoglycemia: The Cause of the Dead in Bed Syndrome?”Int. J. Clin. Pract. Suppl. No. 129, Jul. 2002, pp. 27-32.
Landstedt-Hallin, L., et al., “Increased QT Dispersion During Hypoglycaemia in Patients with Type 2 Diabetes Mellitus,”Journal of Internal Medicine, 1999; vol. 246, pp. 299-307.
Jones, Timothy W., et al., “Mild Hypoglycemia and Impairment of Brain Stem and Cortical Evoked Potentials in Healthy Subjects,”Diabetes, Dec. 1990; vol. 39, pp. 1550-1555.
Peterson, Karl-Georg, et al., “Regulation of Serum Potassium During Insulin-Induced Hypoglycemia,”Diabetes, Jul. 1982; vol. 31, pp. 615-617.
Robinson, R.T.C.E., et al. “Changes in Cardiac Repolarization During Clinical Episodes of Nocturnal Hypoglycaemia in Adults with Type 1 Diabetes,”Diabetologia, 2004; vol. 47, pp. 312-315.
Yanowitz, Frank G., MD, Prof. of Medicine, Univ. of Utah School of Medicine, “Lesson X. ST Segment Abnormalities,” The Alan E. Lindsay—ECG Learning Center—In Cyberspace, 5 pages (http://medstat.med.utah.edu/kw/ecg/ecg—outline/Lesson10/).
Blendea, Mihaela C., MD, PhD, et al, “Heart Disease in Diabetic Patients”Current Diabetes Reports, 2003; vol. 3. pp. 223-229.
Malmberg, Klas for the DIGAMI Study Group, “Prospective Randomised Study of Intensive Insulin Treatment on Long-Term Survival After Acute Myocardial Infarction in Patients with Diabetes Mellitus”,BMJ, May 24, 1997; vol. 314, pp. 1512-1515.
Benser Michael
Bharmi Rupinder
Boileau Peter
Bornzin Gene A.
Florio Joseph J.
Pacesetter Inc.
Schaetzle Kennedy
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