Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2011-07-12
2011-07-12
Casler, Brian (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S473000, C600S476000, C356S073000, C356S318000
Reexamination Certificate
active
07979107
ABSTRACT:
A method for differentiating malignant in vivo liver tissues from normal in vivo liver tissues of a living subject includes the steps of: (a) illuminating a first area and a second area of in vivo liver tissues of the living subject with a first excitation light, (b) measuring an intensity of fluorescent light emitted from each of the first area and the second area of in vivo liver tissues in response to the first excitation light as a function of wavelength so as to obtain a first and a second fluorescent spectra, respectively, (c) illuminating the first area and the second area of in vivo liver tissues with a second excitation light, (d) measuring an intensity of diffuse light reflected by each of the first area and the second area of in vivo liver tissues in response to the second excitation light as a function of wavelength so as to obtain a first and a second diffused reflectance spectra, respectively, and (e) identifying one of the first area and the second area of in vivo liver tissues as malignant liver tissues and the other one of the first area and the second area of in vivo liver tissues as normal liver tissues, by comparing the first fluorescence spectrum and the second florescence spectrum, and comparing the first diffused reflection spectrum and the second diffused reflection spectrum.
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Chari Ravi S.
Lin Wei-Chiang
Mahadevan-Jansen Anita
Toms Steven A.
Casler Brian
Cleveland Clinic Foundation
Kish James
Morris Manning & Martin LLP
Tingkang Xia, Esq. Tim
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