Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-10-17
2011-12-13
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S006110, C435S006180, C435S091200, C436S063000
Reexamination Certificate
active
08076075
ABSTRACT:
An assay for a GCH1 allele and associated genotype for the screening, prediction, diagnosis, prognosis, treatment and treatment response of psychiatric, neuropsychiatric, and neurological disorders, such as schizophrenia, schizoaffective disorder and bipolar disorder, and for defining treatments of such disorders. The presence of a variant in the GCH1 gene, alone or in conjunction with a measurement of low or altered biopterin, or altered BH4 system measures, is used to screen for or diagnose subjects at high risk for developing a psychiatric, neuropsychiatric, or neurological disorders. The assay of the GCH1 genotype, with or without biopterin or a BH4 or BH4 system assay, may also be used to determine antipsychotic or mood stabilizer medication, as well as other treatments. For subjects with an impaired BH4 system, treatments to increase or normalize biopterin, BH4, or the BH4 system can also be used, such as BH4 supplementation, lithium treatment, phenylalanine treatment, or other treatments and therapies.
REFERENCES:
patent: 2007/0254288 (2007-11-01), Woolf et al.
Richardson et al. (Neuropsychobiology, 2005, vol. 52, pp. 190-201).
Genecard GCH1, GTP Cyclohydrolase I, available at www.genecards.org, pp. 1-17.
Holden et al., Medical Hypothess, 1995, vol. 45, pp. 575-587.
Genecard GCH1, GTP Cyclohydrolase I, available at www.genecards.org, pp. 1-17, printed Dec. 2008.
Kealey C. et al. Linkage and Candidate Gene Analysis of 14q22-24 in Bipolar Disorder: Support for GCHI as Novel Susceptibility Gene. Am. J. Medical Genetics Part B (Neuropsychiatric Genetics) 2005, vol. 136B, pp. 75-80.
Hahn, H. et al. Neurological and Psychiatric Manifestations in a Family with a Mutation in Exon 2 of the Guanosine of the Guanosine Triphosphate-Cyclohydrolase Gene. Arch Neurol. 2001, vol. 58, pp. 749-755.
Clelland Catherine L.
Clelland James D.
Bausch Sarae
Bond Schoeneck & King
Nocilly David L.
The Research Foundation for Mental Hygiene, Inc.
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