System and method for controlling electroosmotic flow

Details System and method for controlling electroosmotic flow System and method for controlling electroosmotic flow

1991-09-04

1993-01-19

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

204299R, G01N 2726

Patent

active

051804751

ABSTRACT:
A system and method for controlling the rate of electroosmotic flow in capillary electrophoresis. A first high voltage power supply is electrically connected to the inlet end of a capillary tube, while a second high voltage power supply is connected at an outlet end. The potential difference across the capillary tube is therefore the difference between the high voltages. Electroosmotic flow can be controlled by varying the two high voltages correspondingly to maintain the same potential difference but to achieve a different voltage offset relative to ground. Optionally, the voltage offset may be varied during electrophoresis analysis to slow migration during periods in which constituents are closely spaced and to speed migration when constituents are sufficiently spaced apart. A conductive capillary tube coating which is preferably grounded defines an external control area for electroosmotic flow. A detector is located downstream of the external control area, so that the coating is a unitary layer.

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