System and method for complement pathway analysis

Details System and method for complement pathway analysis System and method for complement pathway analysis

1988-06-30

1990-10-02

Yarbrough, Amelia B.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 7, 436507, 436512, 436536, 436539, 436548, 436809, 436821, G01N 33566

Patent

active

049607120

ABSTRACT:
The present invention relates to systems and methods used to assay for particular complement component fragments. The invention can be used to determine the amount of a particular complement component fragment in a sample. The fragment can be fluid phase or bound to an immune complex. Generally, specific binding agents, such as antibodies, directed to the complement component fragments and immune complexes are used in the assay.

REFERENCES:
patent: 4342566 (1982-08-01), Theofilopoulos et al.
patent: 4642284 (1987-02-01), Cooper et al.
Nydegger and Davis, "Soluble Immune Complexes in Human Disease" in Critical Reviews in Clinical Laboratory Sciences, Batsakis and Savory eds., CRC Press, Inc. Boca Raton, Florida pp. 123-170 (1980).
Lachmann, P. J. et al. J. Exp. Med. 156:205-216 (1982).
Ross, G. D. et al., J. Immunology 129:2051-2060 (1982).
Pussell et al., Lancet, Aug. 12, 1978, pp. 359-365.
Lachmann et al., Immunology Today, Aug. 1981, p. 144.
Theofilopoulos et al., Advances in Immunology, 28:89-220 (1979).
Pangburn et al., J. Immunology, 124:977-982 (1980).
Wilson et al., N. Engl. J. Med., 307:981-986 (1982).
Medof, J. Exp. Med., 156:1739-1754 (Dec. 1982).
Polhill et al., J. Immunology, 121:363-370 (1978).

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